Jia Ruo-Ling, Liu Qing-Ling, Yang Long-Wei, Deng Shi, Song Yang
School of Pharmacy, Xinxiang University, School of Pharmacy, Xinxiang University, Xinxiang 453000, P.R. of China.
West China hospital of Sichuan University, Chengdu, 610041, P.R. of China.
Org Biomol Chem. 2021 Nov 25;19(45):9867-9871. doi: 10.1039/d1ob00854d.
A [6 + 3] annulation reaction of Morita-Baylis-Hillman carbonates and dicyanoheptafulvene is accomplished by employing commercially available triphenylphosphine as the Lewis base catalyst. A spectrum of densely functionalized bicyclo[4.3.1]decane architectures are efficiently constructed with exclusive diastereoselectivity and good yield (up to 95%).
通过使用市售的三苯基膦作为路易斯碱催化剂，实现了森田-贝利斯-希尔曼碳酸酯与二氰基七富烯的[6 + 3]环化反应。一系列密集官能化的双环[4.3.1]癸烷结构得以高效构建，具有专一的非对映选择性和良好的产率（高达95%）。
