Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
Chem Soc Rev. 2021 Dec 13;50(24):13449-13466. doi: 10.1039/d1cs00392e.
Efficient chemical transformation in a green, low-carbon way is crucial for the sustainable development of modern society. Enzyme-photo-coupled catalytic systems (EPCS) that integrate the exceptional selectivity of enzyme catalysis and the unique reactivity of photocatalysis hold great promise in solar-driven 'molecular editing'. However, the involvement of multiple components and catalytic processes challenged the design of efficient and stable EPCS. To show a clear picture of the complex catalytic system, in this review, we analyze EPCS from the perspective of system engineering. First, we disintegrate the complex system into four elementary components, and reorganize these components into biocatalytic and photocatalytic ensembles (BE and PE). By resolving current accessible systems, we identify that connectivity and compatibility between BE and PE are two crucial factors that govern the performance of EPCS. Then, we discuss the origin of undesirable connectivity and low compatibility, and deduce the possible solutions. Based on these understandings, we propose the designing principles of EPCS. Lastly, we provide a future perspective of EPCS.
高效、绿色、低碳的化学转化对于现代社会的可持续发展至关重要。酶-光偶联催化系统（EPCS）将酶催化的非凡选择性和光催化的独特反应性结合在一起，在太阳能驱动的“分子编辑”中具有广阔的应用前景。然而，多种组分和催化过程的参与给高效、稳定的 EPCS 的设计带来了挑战。为了更清晰地了解复杂的催化体系，在这篇综述中，我们从系统工程的角度来分析 EPCS。首先，我们将复杂的体系分解为四个基本组成部分，并将这些组成部分重新组织成生物催化和光催化组件（BE 和 PE）。通过解析现有的可及体系，我们确定了 BE 和 PE 之间的连接性和兼容性是决定 EPCS 性能的两个关键因素。然后，我们讨论了不理想的连接性和低兼容性的起源，并推导出可能的解决方案。基于这些认识，我们提出了 EPCS 的设计原则。最后，我们对 EPCS 的未来进行了展望。
