Ueno Fumihiko, Matsushita Sachio, Hara Sachiko, Oshima Shunji, Roh Sungwon, Ramchandani Vijay A, Mimura Masaru, Uchida Hiroyuki
National Hospital Organization Kurihama Medical and Addiction Center, Yokosuka, Japan.
Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Addiction. 2022 Apr;117(4):934-945. doi: 10.1111/add.15733. Epub 2021 Nov 22.
To investigate the acute effects of intravenous alcohol and its metabolite acetaldehyde on cognitive function in healthy individuals.
Experimental pre-test/post-test design.
Kurihama Medical and Addiction Center, Japan.
A total of 298 healthy Japanese people age 20 to 24 years.
Participants underwent an intravenous alcohol infusion with a target blood alcohol concentration (BAC) of 0.50 mg/mL for 180 minutes. Participants completed the continuous performance test (CPT) for sustained attention, the paced auditory serial addition test (PASAT) for working memory, and the reaction time test (RTT) for speed/accuracy, along with the blood test for BAC and blood acetaldehyde concentration (BAAC) at baseline, 60 and 180 minutes.
Although the target BAC was maintained during the infusion, BAAC peaked at 30 minutes and then gradually declined (η = 0.18, P < 0.01). The CPT scores worsened, and the changes between 0 and 60 minutes were correlated with BAAC (correct detection, η = 0.09, P < 0.01; r = -0.34, P < 0.01; omission errors, η = 0.08, P < 0.01; r = 0.34, P < 0.01). PASAT scores improved through 180 minutes, whereas the changes between 0 and 60 minutes were negatively correlated with BAAC (task one, η = 0.02, P < 0.01; r = -0.25, P < 0.01; task two, η = 0.03, P < 0.01; r = -0.28, P < 0.01). Although RTTs worsened, they were not associated with BAC or BAAC. None of these comparisons maintained the time effect after controlling for body height.
Acetaldehyde exposure following acute intravenous alcohol appears to have a negative impact on sustained attention and working memory, whereas there seems to be only a minor effect of moderate alcohol concentration on speed and accuracy.
研究静脉注射酒精及其代谢产物乙醛对健康个体认知功能的急性影响。
实验前测/后测设计。
日本久里滨医学与成瘾中心。
共298名年龄在20至24岁的健康日本人。
参与者接受静脉注射酒精，目标血液酒精浓度（BAC）为0.50mg/mL，持续180分钟。参与者在基线、60分钟和180分钟时完成用于持续注意力的连续性能测试（CPT）、用于工作记忆的听觉连续加法测试（PASAT）和用于速度/准确性的反应时间测试（RTT），同时进行血液BAC和血液乙醛浓度（BAAC）检测。
尽管在输注过程中目标BAC得以维持，但BAAC在30分钟时达到峰值，然后逐渐下降（η = 0.18，P < 0.01）。CPT分数恶化，0至60分钟之间的变化与BAAC相关（正确检测，η = 0.09，P < 0.01；r = -0.34，P < 0.01；遗漏错误，η = 0.08，P < 0.01；r = 0.34，P < 0.01）。PASAT分数在180分钟内有所改善，而0至60分钟之间的变化与BAAC呈负相关（任务一，η = 0.02，P < 0.01；r = -0.25，P < 0.01；任务二，η = 0.03，P < 0.01；r = -0.28，P < 0.01）。尽管RTT变差，但它们与BAC或BAAC无关。在控制身高后，这些比较均未显示出时间效应。
急性静脉注射酒精后接触乙醛似乎对持续注意力和工作记忆有负面影响，而中等酒精浓度对速度和准确性似乎只有轻微影响。
