Chen Kaiqi, Li Yunhua, Yue Rui, Jin Zhao, Cui Shikui, Zhang Xijian, Zhu Danping, Li Qihui
School of Basic Medical, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
College of Education, Chengdu College of Arts and Sciences, Chengdu, China.
Front Aging Neurosci. 2024 Nov 25;16:1458274. doi: 10.3389/fnagi.2024.1458274. eCollection 2024.
This study aims to explore the association between alcohol intake and cognitive function in elderly Americans, including potential nonlinear relationships and interactions across different subgroups.
The study analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014. The sample included 2,675 Americans aged 60 or older. Multivariate regression analysis was used to evaluate the relationship between alcohol intake and cognitive function. Smooth curve fitting and threshold effect analysis were employed to explore potential nonlinear relationships. Subgroup analyses were conducted to examine the stability of the results across different subgroups.
The results indicate a significant negative correlation between alcohol intake and cognitive function. In the CERAD total word recall test, for every unit increase in alcohol intake, the score decreased by 0.15 points (-0.15, 95% CI: -0.25, -0.04), and in the CERAD delayed recall test, it decreased by 0.07 points (-0.07, 95% CI: -0.12, -0.01). Compared to Non-Heavy Drinkers, Heavy Drinkers showed a reduction in their CERAD total word recall scores by-0.77 points (-0.77, 95% CI: -1.23, -0.32) and in their CERAD delayed recall scores by-0.28 points (-0.28, 95% CI: -0.52, -0.04). Smooth curve fitting analysis revealed a nonlinear relationship between alcohol intake and cognitive function, with breakpoints at 10.7 for the CERAD total word recall test, 4.7 for the Animal fluency test, and 3.85 for the Digit symbol substitution test. Additionally, subgroup analysis indicated that gender, educational level, and smoking status significantly moderated the relationship between alcohol intake and cognitive function, while marital status, race, hypertension, diabetes, and cancer status showed no significant interactions.
The association between alcohol intake and cognitive function in the elderly is complex, influenced by both the amount of intake and individual subgroup characteristics.
本研究旨在探讨美国老年人饮酒与认知功能之间的关联，包括潜在的非线性关系以及不同亚组之间的相互作用。
该研究分析了2011年至2014年美国国家健康与营养检查调查（NHANES）的数据。样本包括2675名60岁及以上的美国人。采用多元回归分析来评估饮酒与认知功能之间的关系。运用平滑曲线拟合和阈值效应分析来探索潜在的非线性关系。进行亚组分析以检验不同亚组结果的稳定性。
结果表明饮酒与认知功能之间存在显著的负相关。在CERAD总单词回忆测试中，饮酒量每增加一个单位，得分下降0.15分（-0.15，95%置信区间：-0.25，-0.04）；在CERAD延迟回忆测试中，得分下降0.07分（-0.07，95%置信区间：-0.12，-0.01）。与非重度饮酒者相比，重度饮酒者的CERAD总单词回忆得分降低了0.77分（-0.77，95%置信区间：-1.23，-0.32），CERAD延迟回忆得分降低了0.28分（-0.28，95%置信区间：-0.52，-0.04）。平滑曲线拟合分析揭示了饮酒与认知功能之间的非线性关系，在CERAD总单词回忆测试中的断点为10.7，动物流畅性测试中的断点为4.7，数字符号替换测试中的断点为3.85。此外，亚组分析表明，性别、教育水平和吸烟状况显著调节了饮酒与认知功能之间的关系，而婚姻状况、种族、高血压、糖尿病和癌症状况未显示出显著的相互作用。
老年人饮酒与认知功能之间的关联较为复杂，受饮酒量和个体亚组特征的影响。
