Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Laboratory of Neuropharmacology, Federal University of Goiás, Goiânia, GO, Brazil.
J Mol Med (Berl). 2022 Feb;100(2):151-165. doi: 10.1007/s00109-021-02157-0. Epub 2021 Nov 4.
Psychological stress predisposes our body to several disorders. Understanding the cellular and molecular mechanisms involved in the physiological responses to psychological stress is essential for the success of therapeutic applications. New studies show, by using in vivo inducible Cre/loxP-mediated approaches in combination with pharmacological blockage, that sympathetic nerves, activated by psychological stress, induce brown adipocytes to produce IL-6. Strikingly, this cytokine promotes gluconeogenesis in hepatocytes, that results in the decline of tolerance to inflammatory organ damage. The comprehension arising from this research will be crucial for the handling of many inflammatory diseases. Here, we review recent advances in our comprehension of the sympathetic nerve-adipocyte axis in the tissue microenvironment.
心理压力使我们的身体容易出现多种紊乱。了解参与心理应激生理反应的细胞和分子机制对于治疗应用的成功至关重要。新的研究表明，通过使用体内诱导型 Cre/loxP 介导的方法结合药理学阻断，由心理应激激活的交感神经诱导棕色脂肪细胞产生白细胞介素 6。引人注目的是，这种细胞因子促进肝细胞中的糖异生，导致对炎症性器官损伤的耐受性下降。从这项研究中获得的认识对于处理许多炎症性疾病至关重要。在这里，我们回顾了我们对组织微环境中交感神经-脂肪细胞轴的理解的最新进展。
