Institute for Developmental Biology and Neurobiology, Cellular Neuroscience, Biology of Extracellular Vesicles, Johannes Gutenberg University Mainz, Mainz, Germany.
Neuron. 2021 Nov 3;109(21):3397-3400. doi: 10.1016/j.neuron.2021.10.016.
Axon integrity depends on support by glia facilitating axonal maintenance and energy homeostasis, but the molecular mechanisms are not well understood. In this issue of Neuron, Chamberlain et al. (2021) provide evidence that oligodendrocyte-to-axon transfer of SIRT2 via extracellular vesicles (exosomes) enables deacetylation of mitochondrial proteins, enhancing axonal energy production.
轴突完整性依赖于神经胶质的支持，从而促进轴突的维持和能量平衡，但分子机制尚不清楚。在本期《神经元》杂志上，Chamberlain 等人提供了证据表明，少突胶质细胞通过细胞外囊泡（外泌体）向轴突转运 SIRT2，使线粒体蛋白去乙酰化，从而增强轴突的能量产生。
