Ahmad Shahzad, Srivastava Rohit K, Singh Pratibha, Naik Ulhas P, Srivastava Amit K
Department of Medical Elementology and Toxicology, Jamia Hamdard University, New Delhi, India.
Department of Pediatric Surgery, Texas Children's Hospital, Houston, TX, United States.
Front Mol Neurosci. 2022 Apr 13;15:844194. doi: 10.3389/fnmol.2022.844194. eCollection 2022.
Cross talk between glia and neurons is crucial for a variety of biological functions, ranging from nervous system development, axonal conduction, synaptic transmission, neural circuit maturation, to homeostasis maintenance. Extracellular vesicles (EVs), which were initially described as cellular debris and were devoid of biological function, are now recognized as key components in cell-cell communication and play a critical role in glia-neuron communication. EVs transport the proteins, lipids, and nucleic acid cargo in intercellular communication, which alters target cells structurally and functionally. A better understanding of the roles of EVs in glia-neuron communication, both in physiological and pathological conditions, can aid in the discovery of novel therapeutic targets and the development of new biomarkers. This review aims to demonstrate that different types of glia and neuronal cells secrete various types of EVs, resulting in specific functions in intercellular communications.
神经胶质细胞与神经元之间的相互作用对于多种生物学功能至关重要，这些功能涵盖神经系统发育、轴突传导、突触传递、神经回路成熟以及内环境稳态维持等方面。细胞外囊泡（EVs）最初被描述为细胞碎片且不具备生物学功能，如今却被公认为细胞间通讯的关键组成部分，并在神经胶质细胞与神经元的通讯中发挥着至关重要的作用。细胞外囊泡在细胞间通讯中运输蛋白质、脂质和核酸货物，从而在结构和功能上改变靶细胞。更好地理解细胞外囊泡在生理和病理条件下神经胶质细胞与神经元通讯中的作用，有助于发现新的治疗靶点并开发新的生物标志物。本综述旨在证明不同类型的神经胶质细胞和神经元细胞分泌各种类型的细胞外囊泡，从而在细胞间通讯中发挥特定功能。
