Hagve T A, Christophersen B, Høie K, Johansen Y
Scand J Clin Lab Invest Suppl. 1986;184:61-6.
The fatty acid pattern in phospholipids of serum and platelets, and conversion of labelled 18:3(n-3) and 20:3(n-6) in cultured lymphocytes was studied in healthy subjects consuming a low fat diet for four weeks. In serum and platelets the level of polyunsaturated C20 and C22 fatty acids was maintained stable, while the content of 18:2(n-6) was significantly decreased. The delta 6-desaturase activity in lymphocytes was increased after the low fat diet, while the rate of delta 5-desaturation was unchanged. It is concluded that the rate of delta 6-desaturation and perhaps also chain-elongation is regulated by the content and composition of dietary lipids in order to maintain the fatty acid pattern of phospholipids stable.
对食用低脂饮食四周的健康受试者的血清和血小板磷脂中的脂肪酸模式，以及培养淋巴细胞中标记的18:3(n-3)和20:3(n-6)的转化情况进行了研究。在血清和血小板中，多不饱和C20和C22脂肪酸水平保持稳定，而18:2(n-6)的含量显著降低。低脂饮食后淋巴细胞中的δ6-去饱和酶活性增加，而δ5-去饱和率未变。得出的结论是，δ6-去饱和率以及可能的链延长率受膳食脂质的含量和组成调节，以维持磷脂的脂肪酸模式稳定。
