CognitionMetrics, LLC, Wilmington, DE, USA.
Biogen, Cambridge, MA, USA.
Parkinsonism Relat Disord. 2021 Nov;92:94-100. doi: 10.1016/j.parkreldis.2021.10.007. Epub 2021 Oct 12.
Individuals with progressive supranuclear palsy (PSP) experience cognitive changes that are challenging to follow without a validated neuropsychological test battery to measure progression. This study describes a composite measure to evaluate cognition in individuals with PSP.
Baseline cognitive test data from 486 participants with PSP in the PASSPORT (NCT03068468) study included the Repeatable Battery for Assessment of Neuropsychological Status (RBANS), Color Trails Test (CTT) parts 1 and 2, letter-number sequencing, and letter fluency. Data were analyzed using summary statistics and a matrix of Pearson correlations. A hypothetical factor structure was constructed and validated.
Observed correlations were highest for scores between story memory and story recall (correlation coefficient = 0.78) and lowest for scores between letter fluency and picture naming (correlation coefficient = 0.11), and picture naming and figure copy (correlation coefficient = 0.12). After excluding picture naming and Color Trails Test (CTT) parts 1 and 2, a 3-factor structure was hypothesized for the remaining 13 tests. Confirmatory factor analysis demonstrated goodness of fit within acceptable limits (comparative fit index and Tucker-Lewis index = 0.98, standardized root-mean-square residual and root-mean-square error of approximation = 0.05-0.06). Mixed-model repeated-measures analysis of change from baseline to week 52 in RBANS and PSP cognitive composite score produced mean-to-standard-deviation ratios of 0.418 and 0.780, respectively.
This novel composite endpoint, based on RBANS and designed to account for motor impairments in PSP, improves on current cognitive assessments PSP.
进行性核上性麻痹（PSP）患者会出现认知变化，如果没有经过验证的神经心理学测试来衡量进展，这些变化很难被跟踪。本研究描述了一种综合措施，用于评估 PSP 患者的认知能力。
PASSPORT（NCT03068468）研究中 486 名 PSP 患者的基线认知测试数据包括重复性成套神经心理状态评估量表（RBANS）、连线测试（CTT）第 1 部分和第 2 部分、数字符号测试和字母流畅性测试。使用汇总统计数据和 Pearson 相关矩阵进行数据分析。构建并验证了一个假设的因素结构。
观察到的相关性最高的是故事记忆和故事回忆之间的分数（相关系数=0.78），最低的是字母流畅性和图片命名之间的分数（相关系数=0.11）以及图片命名和图形复制之间的分数（相关系数=0.12）。在排除图片命名和 CTT 第 1 部分和第 2 部分后，假设了剩余 13 项测试的 3 因素结构。验证性因子分析表明，拟合优度在可接受范围内（比较拟合指数和 Tucker-Lewis 指数=0.98，标准化均方根残差和均方根误差逼近=0.05-0.06）。RBANS 和 PSP 认知综合评分从基线到第 52 周的混合模型重复测量变化分析产生的均值与标准差比值分别为 0.418 和 0.780。
这个新的综合终点，基于 RBANS 并设计用于考虑 PSP 中的运动障碍，改进了当前 PSP 的认知评估。
