Department of Clinical Neurology, University of Oxford, Oxford, UK.
Eur J Neurol. 2010 Feb;17(2):238-41. doi: 10.1111/j.1468-1331.2009.02777.x. Epub 2009 Sep 23.
We aimed to investigate recall of autobiographical memories across lifetime periods in patients with progressive supranuclear palsy (PSP).
Patients with PSP (n = 10) were given a test of autobiographical and personal semantic information and the Addenbrooke's Cognitive Examination (ACE). The result was compared to 30 matched neurologically intact participants.
A mild autobiographical memory impairment was observed in PSP without a temporal gradient for the recall of autobiographical or personal semantic information. Performance correlated with verbal fluency in ACE.
Patients with PSP show mild deficits in autobiographical memory, which is likely to reflect a frontal retrieval deficit.
我们旨在调查进行性核上性麻痹（PSP）患者一生中自传体记忆的回忆情况。
我们对 10 名 PSP 患者进行了自传体和个人语义信息测试以及 Addenbrooke 认知评估（ACE）。结果与 30 名匹配的神经功能正常的参与者进行了比较。
PSP 患者存在轻度自传体记忆障碍，但自传体或个人语义信息的回忆没有时间梯度。在 ACE 中，表现与语言流畅性相关。
PSP 患者表现出轻度的自传体记忆缺陷，这可能反映了额叶提取缺陷。
