Kouba Lamia, Alhosain Dalia
Department of Dermatology, Damascus University Hospitals, Damascus, Syria.
Department of Internal Medicine, Damascus University Hospitals, Damascus, Syria.
Int J Emerg Med. 2021 Nov 4;14(1):65. doi: 10.1186/s12245-021-00389-y.
Psychosis in pregnancy is rare and could be life-threatening. It requires prompt evaluation and proper management accordingly. Anti-N-methyl-d-aspartate receptor (anti-NMDAr) encephalitis following herpes simplex virus (HSV) infection is a rare cause of psychosis during pregnancy.
A 20-year-old woman at 18 weeks gestation presented with agitation and a 3-day history of hallucinations. She had a prior hospitalization for HSV encephalitis 6 weeks before. Her laboratory workup was unremarkable except for positive anti-NMDAr antibodies in the CSF. The patient was treated with high-dose corticosteroids and plasmapheresis, and she was discharged 2 weeks later fully recovered.
Anti-NMDAr encephalitis can be the culprit behind a new-onset of psychosis in pregnancy. Early diagnosis and treatment are crucial.
妊娠期精神病较为罕见，且可能危及生命。因此需要及时评估并进行适当管理。单纯疱疹病毒（HSV）感染后发生的抗N-甲基-D-天冬氨酸受体（抗NMDAr）脑炎是妊娠期精神病的罕见病因。
一名妊娠18周的20岁女性出现躁动，并伴有3天的幻觉病史。她在6周前曾因HSV脑炎住院治疗。除脑脊液中抗NMDAr抗体呈阳性外，她的实验室检查无异常。该患者接受了大剂量皮质类固醇和血浆置换治疗，2周后出院，已完全康复。
抗NMDAr脑炎可能是妊娠期新发精神病的病因。早期诊断和治疗至关重要。
