Department of Pediatrics, E-Da Hospital, No.1, Yi-Da Road, Yan-Chao District, Kaohsiung City, 82445, Taiwan, R.O.C.
School of Medicine, I-Shou University, No. 8, Yi-Da Road, Yan-Chao District, Kaohsiung City, 82445, Taiwan, R.O.C.
BMC Complement Med Ther. 2021 Nov 4;21(1):275. doi: 10.1186/s12906-021-03442-8.
Gastroesophageal reflux disease (GERD) is associated with lower esophageal sphincter (LES) incompetence. In some patients, GERD is refractory to acid reduction therapy which is the main treatment for GERD. So far, medications that can increase LES tone are few. Arecae pericarpium (A. pericarpium) is a medication in Traditional Chinese Medicine known to promote intestinal motility.
We investigated the effect of A. pericarpium extracts on porcine LES motility. In addition, we used tetrodotoxin (TTX) and atropine to study the underlying mechanism of A. pericarpium extracts-induced contractions of LES.
The results of this study showed that A. pericarpium extracts and their main active ingredient, arecoline, can induce the contractions of porcine LES sling and clasp muscles in a dose-response manner. TTX did not have an inhibitory effect on the contractions induced by A. pericarpium extracts and arecoline in LES. However, atropine significantly inhibited A. pericarpium extracts- and arecoline-induced contractions of LES.
A. pericarpium extracts can induce the contractions of porcine LES in a dose dependent manner, possibly through muscarinic receptors, and hence, may be worth developing as an alternative therapy for GERD.
胃食管反流病（GERD）与食管下括约肌（LES）功能不全有关。在一些患者中，GERD 对酸减少治疗（GERD 的主要治疗方法）有抗药性。到目前为止，能够增加 LES 张力的药物很少。槟榔果皮（A. pericarpium）是一种中药，已知能促进肠道蠕动。
我们研究了 A. pericarpium 提取物对猪 LES 运动的影响。此外，我们使用河豚毒素（TTX）和阿托品来研究 A. pericarpium 提取物诱导 LES 收缩的潜在机制。
本研究结果表明，A. pericarpium 提取物及其主要活性成分槟榔碱能以剂量反应的方式诱导猪 LES 吊索和扣带肌收缩。TTX 对 A. pericarpium 提取物和槟榔碱诱导的 LES 收缩没有抑制作用。然而，阿托品显著抑制 A. pericarpium 提取物和槟榔碱诱导的 LES 收缩。
A. pericarpium 提取物能以剂量依赖的方式诱导猪 LES 收缩，可能通过毒蕈碱受体，因此可能值得开发为 GERD 的替代治疗方法。
