Stanford Multidimensional Program for Innovation and Research in the Esophagus (S-MPIRE) Division of Gastroenterology & Hepatology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Clin Transl Gastroenterol. 2018 Mar 29;9(3):137. doi: 10.1038/s41424-018-0010-y.
Baclofen has been shown to decrease reflux events and increase lower esophageal sphincter pressure, yet has never established a clear role in the treatment of gastroesophageal reflux disease (GERD). Lei and colleagues have shown in a recent elegant study that baclofen reduces the frequency and initiation of secondary peristalsis and heightens esophageal sensitivity to capsaicin-mediated stimulation. These findings may help explain both the benefit of baclofen in conditions such as rumination and supragastric belching, as well as the apparent lack of benefit of baclofen and other GABA agonists in long-term treatment of GERD.
巴氯芬已被证明可减少反流事件并增加食管下括约肌压力，但从未在胃食管反流病 (GERD) 的治疗中确立明确的作用。雷及其同事在最近一项优雅的研究中表明，巴氯芬可降低继发性蠕动的频率和起始，并增加食管对辣椒素介导的刺激的敏感性。这些发现可能有助于解释巴氯芬在反刍和胃上打嗝等情况下的益处，以及巴氯芬和其他 GABA 激动剂在 GERD 的长期治疗中似乎没有益处的原因。
