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小儿非酒精性脂肪性肝病。

Pediatric Nonalcoholic Fatty Liver Disease.

机构信息

Children's Hospital Los Angeles, 4650 Sunset Boulevard, MS #78, Los Angeles, CA 90027, USA.

Children's Hospital Los Angeles, 4650 Sunset Boulevard, MS #78, Los Angeles, CA 90027, USA.

出版信息

Pediatr Clin North Am. 2021 Dec;68(6):1309-1320. doi: 10.1016/j.pcl.2021.07.013.

Abstract

Obesity has led fatty liver disease to become the most common chronic liver disease in children worldwide. Pediatric professional organizations have agreed that screening for fatty liver disease in children is the need of the hour. Once identified, prevention is key through appropriate dietary and activity prescriptions. Research continues to identify key pathways and genetic risk factors that predispose certain children to the more severe manifestations of this silent epidemic. We hope these novel observations lead to breakthrough treatments for these children that are severely impacted, such that they may no longer need liver transplantation as young adults.

摘要

肥胖症已导致脂肪肝疾病成为全球儿童中最常见的慢性肝病。儿科专业组织已达成共识,即对儿童脂肪肝疾病进行筛查势在必行。一旦发现,通过适当的饮食和活动处方进行预防是关键。研究继续确定关键途径和遗传风险因素,这些因素使某些儿童更容易出现这种无声流行的更严重表现。我们希望这些新的观察结果能为这些受严重影响的儿童带来突破性的治疗方法,使他们在成年后不再需要进行肝移植。

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