代谢相关脂肪性肝病中双向免疫交叉对话。
The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease.
机构信息
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
出版信息
Cell Metab. 2023 Nov 7;35(11):1852-1871. doi: 10.1016/j.cmet.2023.10.009.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an unabated risk factor for end-stage liver diseases with no available therapies. Dysregulated immune responses are critical culprits of MASLD pathogenesis. Independent contributions from either the innate or adaptive arms of the immune system or their unidirectional interplay are commonly studied in MASLD. However, the bidirectional communication between innate and adaptive immune systems and its impact on MASLD remain insufficiently understood. Given that both innate and adaptive immune cells are indispensable for the development and progression of inflammation in MASLD, elucidating pathogenic contributions stemming from the bidirectional interplay between these two arms holds potential for development of novel therapeutics for MASLD. Here, we review the immune cell types and bidirectional pathways that influence the pathogenesis of MASLD and highlight potential pharmacologic approaches to combat MASLD based on current knowledge of this bidirectional crosstalk.
代谢相关脂肪性肝病（MASLD）是终末期肝病的一个持续存在的危险因素，目前尚无可用的治疗方法。免疫反应失调是 MASLD 发病机制的关键罪魁祸首。MASLD 的发病机制研究通常侧重于固有免疫或适应性免疫系统的单独作用，或者它们的单向相互作用。然而，固有免疫和适应性免疫系统之间的双向通信及其对 MASLD 的影响仍了解不足。鉴于固有免疫和适应性免疫细胞对于 MASLD 中的炎症的发生和发展都是不可或缺的，阐明源自这两个分支之间的双向相互作用的致病贡献有可能为 MASLD 开发新的治疗方法。在这里，我们综述了影响 MASLD 发病机制的免疫细胞类型和双向途径，并根据对这种双向串扰的现有知识，强调了基于潜在的药理学方法来对抗 MASLD。
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