Micro et Nanomédecines Translationnelles, MINT, UNIV Angers, UMR INSERM 1066, UMR CNRS 6021, Angers, France.
Micro et Nanomédecines Translationnelles, MINT, UNIV Angers, UMR INSERM 1066, UMR CNRS 6021, Angers, France.
Eur J Pharm Biopharm. 2021 Dec;169:220-240. doi: 10.1016/j.ejpb.2021.10.015. Epub 2021 Nov 1.
The healthy human body is inhabited with a large number of bacteria, forming natural flora. It is even estimated that for a human body, its amount of DNA is less important that its bacterial genetic material. This flora plays major roles in the sickness and health of the human body and any change in its composition may lead to different diseases. Nanoparticles are widely used in numerous fields: cosmetics, food, industry, and as drug delivery carrier in the medical field. Being included in these various applications, nanoparticles may interact with the human body at various levels and with different mechanisms. These interactions differ depending on the nanoparticle nature, its structure, its concentration and manifest in different ways on the microbiota, leading to its destabilization, its restoring or showing no toxic effect. Nanoparticles may also be used as a vehicle to regulate the microbiota or to treat some of its diseases.
健康人体中栖息着大量细菌，形成自然菌群。甚至有人估计，对于人体而言，其细菌遗传物质比 DNA 的量更为重要。这种菌群在人体的疾病与健康方面起着重要作用，其组成的任何变化都可能导致不同的疾病。纳米颗粒在许多领域得到广泛应用：化妆品、食品、工业，以及作为医学领域的药物输送载体。由于被纳入这些各种应用中，纳米颗粒可能会以不同的机制在不同层面与人体相互作用。这些相互作用取决于纳米颗粒的性质、结构、浓度，并以不同的方式表现在微生物群上，导致其不稳定、恢复或没有毒性作用。纳米颗粒也可以用作调节微生物群或治疗其某些疾病的载体。
