Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Sci Rep. 2021 Nov 4;11(1):21674. doi: 10.1038/s41598-021-00728-2.
For chronic obstructive pulmonary disease (COPD), the role of physical activity in reducing COPD mortality and heart loading and in extending life expectancy remains unclear. Participants in comprehensive medical screening were recruited with spirometry on everyone. We analyzed physical activity volume calculated from intensity, duration and frequency of self-reported exercise history. Deaths were identified from the National Death File. The impacts of physical activity on mortality, heart rate and life expectancy were analyzed. Among the cohort of 483,603 adults, 32,535 had spirometry-determined COPD, indicating an adjusted national prevalence of 11.4% (male) and 9.8% (female). On the average, COPD increased all-cause mortality with a hazard ratio of 1.44 and loss of 6.0 years in life expectancy. Almost two thirds (65%) of the causes of deaths were extra-pulmonary, such as cardiovascular disease, diabetes, cancer and kidney diseases. In addition, COPD was associated with increases in heart rate proportionate to its severity, which led to higher mortality. Participants with COPD who were fully active physically could reduce mortality and have improved heart rates as compared with those without physical activity. In addition, their life expectancy could be extended close to those of the no COPD but inactive cohort. Fully active physical activity can help patients with COPD overcome most of the mortality risks, decrease heart rate, and achieve a life expectancy close to that of patients without COPD. The effectiveness of physical activity on COPD is facilitated by its systemic nature beyond lung disease.
对于慢性阻塞性肺疾病（COPD），体力活动在降低 COPD 死亡率、减轻心脏负荷和延长预期寿命方面的作用尚不清楚。通过对每个人进行肺活量测定来招募全面医学筛查的参与者。我们分析了根据自我报告的运动史的强度、持续时间和频率计算得出的体力活动量。通过国家死亡档案确定死亡人数。分析了体力活动对死亡率、心率和预期寿命的影响。在 483603 名成年人队列中，32535 人有肺活量测定法确定的 COPD，表明调整后的全国患病率为 11.4%（男性）和 9.8%（女性）。平均而言，COPD 使全因死亡率增加，风险比为 1.44，预期寿命损失 6.0 年。近三分之二（65%）的死亡原因是肺外原因，如心血管疾病、糖尿病、癌症和肾脏疾病。此外，COPD 与心率成比例增加有关，这导致了更高的死亡率。与没有体力活动的患者相比，完全活跃的 COPD 患者可以降低死亡率，改善心率，并且预期寿命可以接近没有 COPD 但不活跃的队列。完全积极的体育活动可以帮助 COPD 患者克服大多数死亡风险，降低心率，并实现接近没有 COPD 的患者的预期寿命。体力活动对 COPD 的有效性得益于其超越肺部疾病的全身性。
