头颈部癌患者5-氟尿嘧啶输注相关的高氨血症性脑病：病例报告及文献复习

Hyperammonemic Encephalopathy Associated with 5-Flurouracil Infusion in Head and Neck Cancer: Case Report and Review of the Literature.

作者信息

Das Saikat, Ahmad Aftab, Prasun Pallav, Kharade Vipin, Gupta Manish

机构信息

Department of Radiotherapy, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.

出版信息

J Neurosci Rural Pract. 2021 Sep 28;12(4):811-812. doi: 10.1055/s-0041-1736154. eCollection 2021 Oct.

DOI:10.1055/s-0041-1736154

PMID:34737523

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8559066/

Abstract

Hyperammonemic encephalopathy is an uncommon, potentially lethal adverse effect of 5-fluorouracil (5-FU). Being one of the most common and versatile chemotherapy agents, it is important to understand this important side effect of 5FU. There is paucity of data in this subject. Here, we report a case of 5FU-induced encephalopathy in a patient on induction chemotherapy for head and neck cancer. In this case report, the clinical presentation, diagnosis, and management of 5FU-induced encephalopathy is reported.

摘要

高氨血症性脑病是5-氟尿嘧啶（5-FU）一种罕见的、潜在致命的不良反应。作为最常用且用途广泛的化疗药物之一，了解5-FU的这一重要副作用很重要。关于该主题的数据较少。在此，我们报告1例在接受头颈部癌诱导化疗的患者中发生的5-FU诱导的脑病。在本病例报告中，报道了5-FU诱导的脑病的临床表现、诊断及治疗。