一名接受顺铂和5-氟尿嘧啶治疗的IV期宫颈癌患者的化疗相关性脑病：病例报告
Chemotherapy related encephalopathy in a patient with Stage IV cervical carcinoma treated with cisplatin and 5-fluorouracil: a case report.
作者信息
Chue Amy L, Fernando Indrajit N, Hussain Syed A, Yates David A
机构信息
Oncology Department, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, West Midlands, UK.
出版信息
Cases J. 2009 Jul 30;2:8526. doi: 10.4076/1757-1626-2-8526.
INTRODUCTION
Chemotherapy related encephalopathy is commonly reported with certain forms of chemotherapy but few reports note an association with low dose 5-Fluorouracil.
CASE PRESENTATION
A 57-year-old Caucasian lady received her first cycle of Cisplatin and 5-Fluorouracil for palliative treatment of cervical carcinoma, and presented several days later with signs of encephalopathy. Several causes were eliminated, and encephalopathy related to 5-Fluorouracil was thought to be the most likely cause. Magnetic Resonance Imaging of the head revealed changes related to the chemotherapy received. Symptoms resolved completely within three days of presentation.
CONCLUSION
Encephalopathy from low dose 5-Fluorouracil is not well documented in the literature. Fluid rehydration and supportive treatment is required. Signs and symptoms resolved completely with no residual effects on follow up.
引言
化疗相关性脑病在某些化疗形式中常有报道，但很少有报告指出其与低剂量5-氟尿嘧啶有关。
病例介绍
一名57岁的白人女性接受了顺铂和5-氟尿嘧啶的首个疗程以姑息治疗宫颈癌，几天后出现脑病症状。排除了多种病因后，认为与5-氟尿嘧啶相关的脑病是最可能的病因。头部磁共振成像显示与所接受的化疗有关的变化。症状在出现后的三天内完全缓解。
结论
低剂量5-氟尿嘧啶所致的脑病在文献中记录不多。需要进行液体补充和支持治疗。体征和症状完全缓解，随访无残留影响。
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