Wei Lifang, Li Ye, Yu Yue, Xu Minmin, Chen Huilan, Li Lijie, Peng Ting, Zhao Kang, Zhuang Yongze
Department of Nephrology, The Third People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, People's Republic of China.
The Third People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, People's Republic of China.
Diabetes Metab Syndr Obes. 2021 Oct 28;14:4371-4380. doi: 10.2147/DMSO.S334199. eCollection 2021.
Obesity-related glomerulopathy (ORG) is a secondary glomerular disease caused by obesity, with clinical manifestations such as proteinuria and glomerulomegaly. Currently, the high incidence of obesity brings a change in the spectrum of kidney diseases across the globe, including China. ORG has become another important secondary nephropathy leading to end-stage renal disease (ESRD), and its incidence has increased significantly. This trend is bound to bring about a serious socioeconomic burden. Therefore, it is urgent to study its pathogenesis and intervention measures. Currently, the occurrence and development mechanisms in ORG are complicated by many factors, which are still unclear. In the past 20 years, with the continuous intensive research on mechanisms such as hypoxia in the metabolic process, immune inflammation, and pyroptosis, there have been new advances in the mechanism of ORG, especially the important role of inflammation in podocyte injury and its impact on the progress of ORG. Here, we briefly review the possible pathogenic role of the inflammasome in the podocyte damage in ORG and summarize the possible therapeutical strategies targeting inflammasome.
肥胖相关性肾小球病（ORG）是一种由肥胖引起的继发性肾小球疾病，临床表现为蛋白尿和肾小球肿大。目前，肥胖的高发病率导致全球包括中国在内的肾脏疾病谱发生变化。ORG已成为导致终末期肾病（ESRD）的另一种重要的继发性肾病，其发病率显著增加。这种趋势必然会带来严重的社会经济负担。因此，迫切需要研究其发病机制和干预措施。目前，ORG的发生和发展机制受多种因素影响，仍不明确。在过去20年里，随着对代谢过程中的缺氧、免疫炎症和细胞焦亡等机制的深入研究，ORG的机制有了新进展，尤其是炎症在足细胞损伤中的重要作用及其对ORG进展的影响。在此，我们简要综述炎性小体在ORG足细胞损伤中可能的致病作用，并总结针对炎性小体的可能治疗策略。
