433例肺血栓栓塞症患者的CRP、抗凝血酶、纤维蛋白原及血液学变化分析
Analysis of CRP, Antithrombin, Fibrinogen, and Hematological Changes in 433 Patients with PTE.
作者信息
Wu Yu-Yan, Tan Yong, Yan Min, Cheng Zhen, Pan Xiang-Tao
机构信息
Department of Hematology, Taicang Hospital of Soochow University, Taicang, Jiangsu, People's Republic of China.
出版信息
Int J Gen Med. 2021 Oct 27;14:7181-7185. doi: 10.2147/IJGM.S333747. eCollection 2021.
OBJECTIVE
To investigate the characteristics of coagulation indicators, such as C-reactive protein (CRP), antithrombin (AT), and fibrinogen (FB) in patients with pulmonary thromboembolism (PTE) and their relationship with PTE.
METHODS
The clinical characteristics, CRP, AT, FB, plasma D-dimer (D-D) and platelet (PLT) counts, and blood coagulation indicators of 433 patients with PTE diagnosed by computed tomographic pulmonary angiography (CTPA) were comprehensively analyzed, and the relevant clinical significance was discussed.
RESULTS
The total incidence of PTE was 1.60% (433/270,983 cases), and the age group with the highest incidence was over 60 years old. D-D increased in 412 (95.2%) patients. PLT was normal in 331 (76.4%) cases, but decreased in 53 (12.3%) cases and increased in 49 (11.3%) cases. CRP increased in 76.0% (288/379 cases) and was normal in 24.0% (91/379 cases). AT decreased in 109 (25.2%) cases and FB increased in 102 (23.6%) cases. There were no significant changes in other coagulation indexes. CRP was positively correlated with PLT and FB (r = 0.1026, t = 2.0118, P < 0.05, and r = 0.5360, t = 12.2963, P < 0.01, respectively). CRP was negatively correlated with AT (r = -0.2005, t = 4.0100, P < 0.01).
CONCLUSION
The incidence of PTE was higher in hospitalized patients. Most patients with PTE have increased CRP and FB and decreased AT, and these levels may be related to the occurrence of PTE.
目的
探讨肺血栓栓塞症（PTE）患者C反应蛋白（CRP）、抗凝血酶（AT）、纤维蛋白原（FB）等凝血指标特点及其与PTE的关系。
方法
综合分析433例经计算机断层扫描肺动脉造影（CTPA）确诊的PTE患者的临床特征、CRP、AT、FB、血浆D-二聚体（D-D）及血小板（PLT）计数和凝血指标，并探讨其相关临床意义。
结果
PTE总发病率为1.60%（433/270983例），发病率最高的年龄组为60岁以上。412例（95.2%）患者D-D升高。331例（76.4%）患者PLT正常，53例（12.3%）患者PLT降低，49例（11.3%）患者PLT升高。379例中76.0%（288/379例）CRP升高，24.0%（91/379例）CRP正常。109例（25.2%）患者AT降低，102例（23.6%）患者FB升高。其他凝血指标无明显变化。CRP与PLT、FB呈正相关（r分别为0.1026、t = 2.0118、P < 0.05以及r = 0.5360、t = 12.2963、P < 0.01）。CRP与AT呈负相关（r = -0.2005、t = 4.0100、P < 0.01）。
结论
住院患者中PTE发病率较高。多数PTE患者CRP、FB升高，AT降低，这些指标水平可能与PTE的发生有关。
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