共表达网络分析确定了在非洲裔前列腺癌中具有潜在相关性的长链非编码RNA-信使核糖核酸。
Coexpression network analysis identified lncRNAs-mRNAs with potential relevance in African ancestry prostate cancer.
作者信息
Parra-Medina Rafael, López-Kleine Liliana, Ramírez-Clavijo Sandra, Payán-Gómez César
机构信息
Faculty of Natural Sciences, Universidad del Rosario, Bogotá, Colombia.
Department of Pathology, Research Institute, Fundación Univeristaria de Ciencias de la Salud, Bogotá, Colombia.
出版信息
Future Sci OA. 2021 Sep 22;7(9):FSO749. doi: 10.2144/fsoa-2021-0076. eCollection 2021 Oct.
AIM
This study aims to investigate similarities and differences using lncRNA and mRNA coexpression network analysis in African ancestry (AA) and European ancestry (EA) among prostate cancer (PCa) patients.
METHODS
We performed weighted gene coexpression network analysis of the expression from 49 of AA and 49 of EA to identify lncRNAs-mRNAs.
RESULTS
27 lncRNAs and 36 mRNAs were highly expressed in patients of AA. Two mRNAs and their antisense lncRNAs were expressed. Additionally, seven mRNAs were DE or coexpressed and had an impact on survival.
CONCLUSION
We present a list of lncRNAs and mRNAs that were DE and coexpressed when comparing patients of AA and EA, and these data are a resource for future studies to understand the role of lncRNAs.
目的
本研究旨在通过lncRNA和mRNA共表达网络分析，调查前列腺癌（PCa）患者中非洲血统（AA）和欧洲血统（EA）之间的异同。
方法
我们对49名AA患者和49名EA患者的表达进行了加权基因共表达网络分析，以鉴定lncRNAs-mRNAs。
结果
27种lncRNAs和36种mRNAs在AA患者中高表达。两种mRNAs及其反义lncRNAs表达。此外，7种mRNAs差异表达或共表达，并对生存有影响。
结论
我们列出了在比较AA和EA患者时差异表达和共表达的lncRNAs和mRNAs清单，这些数据为未来研究了解lncRNAs的作用提供了资源。
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