Giribaldi Giuliana, Filippini Claudia, Viberti Clara, Khadjavi Amina, Finesso Nicole, Ulliers Daniela, Turini Stefano, Bressan Bruno Emilio, Pecoraro Francesca, Prato Mauro, Allione Alessandra, Bellis Matteo De, Montefusco Gabriele, Bonomessi Giulia, Allasia Marco, Matullo Giuseppe, Soria Francesco, Gontero Paolo
Department of Oncology, University of Turin, Turin, Italy.
Department of Surgical Sciences, University of Turin, Turin, Italy.
Future Sci OA. 2021 Oct 11;7(9):FSO758. doi: 10.2144/fsoa-2021-0060. eCollection 2021 Oct.
To evaluate the performance of urinary fibrinogen β-chain (FBC) - either alone or associated with urinary tyrosine-phosphorylated proteins (UPY) - as bladder cancer (BCa) diagnostic biomarker.
MATERIALS & METHODS: 164 subjects were tested.
Significantly different FBC and UPY levels were found between BCa patients and controls, as well as between low-grade and high-grade cancers. The diagnostic accuracy was 0.84 for FBC and 0.87 for UPY. The combination of FBC and UPY improved the accuracy to 0.91. The addition of clinical variables (age, gender, and smoking habit) to FBC and UPY into a model for BCa prediction significantly improved the accuracy to 0.99. The combination of FBC and UPY adjusted for clinical variables associates with the highest sensitivity and good specificity.
Urinary FBC and UPY could be used as biomarkers for BCa diagnosis.
评估尿纤维蛋白原β链（FBC）单独或与尿酪氨酸磷酸化蛋白（UPY）联合作为膀胱癌（BCa）诊断生物标志物的性能。
对164名受试者进行了检测。
BCa患者与对照组之间以及低级别和高级别癌症之间的FBC和UPY水平存在显著差异。FBC的诊断准确率为0.84，UPY为0.87。FBC和UPY联合使用可将准确率提高到0.91。将临床变量（年龄、性别和吸烟习惯）添加到FBC和UPY中用于BCa预测模型，可显著提高准确率至0.99。针对临床变量进行调整后的FBC和UPY联合使用具有最高的敏感性和良好的特异性。
尿FBC和UPY可作为BCa诊断的生物标志物。
