Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Sydney Melanoma Diagnostic Centre, Sydney, NSW, Australia.
Pediatr Dermatol. 2021 Nov;38(6):1549-1552. doi: 10.1111/pde.14846. Epub 2021 Nov 4.
A 3.5-month-old boy presented with a changing medium-sized congenital melanocytic nevus on his leg. Due to atypical features on dermoscopy and reflectance confocal microscopy (RCM), an excision of the area of concern was performed. Histopathology showed many of the pathological features usually associated with a diagnosis of melanoma in situ in older patients, but due to the young age of the patient, absence of mitoses, and the degree of atypia, a diagnosis of a dysplastic compound nevus arising in a congenital compound (predominantly dermal) nevus was favored. In our case, RCM corresponded to histopathology helped target the area of concern and map the clinical and subclinical components to facilitate an optimal biopsy.
一位 3.5 个月大的男婴，腿部有一处不断变化的中型先天性黑色素痣。由于皮肤镜和反射式共聚焦显微镜（RCM）检查具有非典型特征，对可疑区域进行了切除。组织病理学检查显示出许多与老年患者原位黑色素瘤诊断相关的病理特征，但由于患者年龄较小，无有丝分裂，且非典型程度，因此更倾向于诊断为在先天性复合（主要是真皮）痣中发生的发育不良复合痣。在我们的病例中，RCM 与组织病理学相对应，有助于确定关注区域，并绘制临床和亚临床成分图，以促进最佳活检。
