Grupo Reproducción, Departamento de Microbiología y Parasitología, Universidad de Antioquia UdeA, Medellín, Colombia.
Department of Rheumatology and Clinical Immunology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Am J Reprod Immunol. 2022 Jan;87(1):e13509. doi: 10.1111/aji.13509. Epub 2021 Dec 4.
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by venous, arterial, or small-vessel thrombosis and/or pregnancy-related morbidity, associated with persistent positivity of antiphospholipid antibodies (aPL). Pregnancy-related morbidity in APS patients is characterized by unexplained fetal deaths, premature birth of morphologically normal newborns, and/or consecutive pregnancy losses before the 10 week of gestation. Beta 2-glycoprotein 1 (ß2GP1) is the main antigen recognized by aPL and plays an essential role in the pathogenesis of APS. Antibodies against ß2GP1 (aß2GP1) are involved in damage-generating mechanisms in APS due to their interaction with trophoblasts, decidua, and endothelial cells. aß2GP1 might be used as a prognostic tool for obstetric risk stratification and ß2GP1 could be a target for molecular-targeted treatment to prevent pregnancy morbidity in APS. This review describes these aspects of aß2GP1, including effects on different cellular targets, its association with the severity of obstetric manifestations and the potential of ß2GP1-targeted therapies for APS.
抗磷脂综合征（APS）是一种自身免疫性疾病，其特征是静脉、动脉或小血管血栓形成和/或与妊娠相关的发病率，与抗磷脂抗体（aPL）持续阳性相关。APS 患者的妊娠相关发病率表现为不明原因的胎儿死亡、形态正常的新生儿早产，和/或连续妊娠丢失发生在妊娠 10 周之前。β2-糖蛋白 1（ß2GP1）是 aPL 识别的主要抗原，在 APS 的发病机制中起重要作用。抗β2-糖蛋白 1（aß2GP1）抗体由于与滋养层细胞、蜕膜和内皮细胞相互作用而参与 APS 的损伤发生机制。aß2GP1 可作为产科风险分层的预后工具，ß2GP1 可能是分子靶向治疗的靶点，以预防 APS 的妊娠发病率。本综述描述了 aß2GP1 的这些方面，包括对不同细胞靶标的影响、与产科表现严重程度的关联以及ß2GP1 靶向治疗 APS 的潜力。
