Shoenfeld Yehuda, Twig Gilad, Katz Uriel, Sherer Yaniv
Department of Medicine B, Sheba Medical Center, Tel-Hashomer, Tel-Aviv University, Israel.
J Autoimmun. 2008 Feb-Mar;30(1-2):74-83. doi: 10.1016/j.jaut.2007.11.011. Epub 2008 Jan 2.
Antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy loss in the presence of antiphospholipid antibodies (aPL), mainly anticardiolipin, anti-beta2-glycoprotein I and lupus anticoagulant. However, similar to systemic lupus erythematosus, APS is also characterized by multiple other autoantibodies including 'non-classical' aPL, as well as other antibodies. Herein we describe the autoantigen properties, prevalence and clinical importance of 30 different antibodies in APS. Among the other antibodies characterizing APS are autoantibodies directed to platelets, glycoproteins, various coagulation factors, lamins, mitochondrial antigens and cell surface markers. Few of these autoantibodies are correlated with the presence of other antibodies, and some may have an additive role in the pro-thrombotic tendency of the syndrome. This autoantibody explosion might be important in early identification of the syndrome and its manifestations.
抗磷脂综合征（APS）的特征是在存在抗磷脂抗体（aPL）的情况下发生血栓形成和妊娠丢失，主要是抗心磷脂抗体、抗β2糖蛋白I抗体和狼疮抗凝物。然而，与系统性红斑狼疮相似，APS的特征还包括多种其他自身抗体，包括“非经典”aPL以及其他抗体。在此我们描述APS中30种不同抗体的自身抗原特性、患病率及临床重要性。表征APS的其他抗体包括针对血小板、糖蛋白、各种凝血因子、核纤层蛋白、线粒体抗原和细胞表面标志物的自身抗体。这些自身抗体中很少有与其他抗体的存在相关，有些可能在该综合征的促血栓形成倾向中起累加作用。这种自身抗体激增可能对该综合征及其表现的早期识别很重要。
