Wang Yue, Yang Kai-Lin, He Chun-Nian, Xiao Pei-Gen
Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medicinal College Beijing 100193, China Key Laboratory of Bioactive Substances and Resources Utilisation of Chinese Herbal Medicine, Ministry of Education Beijing 100193, China.
Zhongguo Zhong Yao Za Zhi. 2021 Oct;46(20):5159-5165. doi: 10.19540/j.cnki.cjcmm.20210725.101.
Withania somnifera, also known as Indian ginseng, is an important traditional medicine in the Ayurvedic medical system of India, which has a significant effect of adaptation. Modern studies have shown that the main chemical components of W. somnifera are withanolides, which have antioxidant, anti-tumor, enhancing immunity, cardiovascular protection, neuroprotection, anti-stress, anti-stress reaction and hypoglycemic activities. Studies on human, animal, mutagenesis, genotoxicity, reproductive toxicity and drug interaction showed that W. somnifera had good safety. Clinical trials have proved that W. somnifera is effective in treating a variety of human diseases. As a famous traditional medicine and modern dietary supplement, it has a high reputation and market in the international health product market, but in China, there is little scientific research, market development, product introduction and application. In this paper, the traditional application, chemical composition, pharmacological activity, safety evaluation and clinical study of the plant were introduced, so as to increase the understanding of the dual use of the plant, and to provide reference for the future introduction of the product, the service to the health of the Chinese people and the promotion of the "double cycle" of the trade of health products between China and the international community.
睡茄，也被称为印度人参，是印度阿育吠陀医学体系中的一种重要传统药物，具有显著的适应原作用。现代研究表明，睡茄的主要化学成分是睡茄内酯，具有抗氧化、抗肿瘤、增强免疫力、心血管保护、神经保护、抗应激、抗应激反应和降血糖活性。对人体、动物、诱变、遗传毒性、生殖毒性和药物相互作用的研究表明，睡茄具有良好的安全性。临床试验证明，睡茄对治疗多种人类疾病有效。作为一种著名的传统药物和现代膳食补充剂，它在国际保健品市场上享有很高的声誉和市场，但在中国，相关的科研、市场开发、产品介绍和应用却很少。本文介绍了该植物的传统应用、化学成分、药理活性、安全性评价和临床研究，以增进对该植物两用性的了解，为今后产品引进、服务中国人民健康以及促进中国与国际社会保健品贸易“双循环”提供参考。
