[来自云实的新型二苯并恶嗪衍生物]

[New dibenzoxocin derivatives from Caesalpinia decapetala].

作者信息

Lei Yan, Jiang Li, Liu Jun-Hong, Lu Yuan, Ma Xue, Zheng Lin, Li Yong-Jun

机构信息

Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education),State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University Guiyang 550004, China School of Pharmaceutical Sciences, Guizhou Medical University Guiyang 550004, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2021 Oct;46(20):5310-5313. doi: 10.19540/j.cnki.cjcmm.20210618.201.

DOI:10.19540/j.cnki.cjcmm.20210618.201

PMID:34738434

Abstract

The present study investigated the chemical constituents of Caesalpinia decapetala in the Fabaceae family. The chemical constituents were isolated and purified by chromatographies with silica gel, RP-C_(18), Sephadex LH-20, and preparative HPLC, and their structures were determined based on the spectroscopic data and physicochemical properties, as well as relevant references. Three pairs of new dibenzoxocin derivatives were isolated from 70% ethanol extract of C. decapetala and identified as protosappanoside A(1 a), isoprotosappanoside A(1 b), protosappanoside B(2 a), isoprotosappanoside B(2 b), protosappanoside C(3 a), and isoprotosappanoside C(3 b), respectively.

摘要

本研究对豆科云实的化学成分进行了研究。通过硅胶柱色谱、RP-C₁₈柱色谱、Sephadex LH-20柱色谱和制备型高效液相色谱对化学成分进行分离和纯化，并根据光谱数据、理化性质以及相关参考文献确定其结构。从云实70%乙醇提取物中分离得到三对新的二苯并恶嗪衍生物，分别鉴定为原苏木皂苷A(1a)、异原苏木皂苷A(1b)、原苏木皂苷B(2a)、异原苏木皂苷B(2b)、原苏木皂苷C(3a)和异原苏木皂苷C(3b)。