a:1:{s:5:"en_US";s:59:"Universidade Federal de Ciências da Saúde de Porto Alegre";}.
Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Avenida Sarmento Leite 245, 90050-170, Porto Alegre, RS, Brazil..
Acta Biomed. 2021 Nov 3;92(5):e2021305. doi: 10.23750/abm.v92i5.10355.
The literature describes that the renowned artwork of the genius of human anatomy, Leonardo da Vinci (1452-1519), known as Mona Lisa (1503-1506), is among one of the most enigmatic artworks in the History of Art. In this context, many details inserted on the composition of this artwork, including those related to Mona Lisa physical aspects' (anatomy) are controversial. The few known descriptions that provide some thorough indications about the woman who served as the model for this work, were written by Giorgio Vasari (1511-1574) in 1550. According to Vasari, the Mona Lisa is a portrait of Lisa del Giocondo (1479-1542) and although he has given a detailed description concerning Lisa's physical characteristics, some are not fully understood so far. In this context, the unequal size of her pupils stands out, a clinical condition known as anisocoria. On this detail, this Letter presents unprecedented pieces of evidence that the anisocoria represented in Mona Lisa may be an indicator that Lisa del Giocondo had a neurological disorder known as Holmes-Adie Syndrome, which could have been caused by an endocrine disruption of the thyroid hormones. Thus, the pieces of information presented on this Letter are essential for further studies once, through them, it is possible to know more about the physical characteristics and also about the probable health condition of the renowned character of one of the most famous artworks of history.
文献描述，人类解剖学天才列奥纳多·达·芬奇（Leonardo da Vinci，1452-1519 年）的著名作品《蒙娜丽莎》（Mona Lisa，1503-1506 年），是艺术史上最神秘的作品之一。在这种情况下，这幅作品的构图中插入了许多有争议的细节，包括与蒙娜丽莎身体方面（解剖学）相关的细节。为数不多的已知描述是由乔治·瓦萨里（Giorgio Vasari，1511-1574 年）于 1550 年撰写的，这些描述提供了一些关于作为这幅作品模特的女性的详细信息。根据瓦萨里的说法，《蒙娜丽莎》是丽莎·德尔·吉奥孔多（Lisa del Giocondo，1479-1542 年）的肖像画，尽管他对丽莎的身体特征进行了详细描述，但有些特征迄今仍未完全理解。在这种情况下，她瞳孔的大小不等引人注目，这是一种称为虹膜异色症的临床病症。关于这一细节，这封信提出了前所未有的证据，表明《蒙娜丽莎》中所呈现的虹膜异色症可能是丽莎·德尔·吉奥孔多患有霍姆斯-阿迪综合征的神经紊乱的一个指标，这种紊乱可能是由于甲状腺激素的内分泌失调引起的。因此，这封信中所呈现的信息对于进一步的研究至关重要，因为通过这些信息，我们可以更多地了解这位历史上最著名的艺术作品之一的著名人物的身体特征和可能的健康状况。
