Malberger E, Gutterman E, Bartfeld E, Zajicek G
Acta Cytol. 1987 May-Jun;31(3):305-8.
While examining fine needle aspirates of lesions, it became evident that preovulatory aspirates differed from postovulatory ones. Proliferation activity was noted in cells and in fragments aspirated during the luteal phase. In order to verify this observation, pairs of smears obtained during different phases of the menstrual cycle from eight fertile women were studied by computer image analysis. Using discriminant analysis based on nuclear features extracted from the digitized cell images, 84.87% of all cells were correctly classified as preovulatory or postovulatory, according to the smear of origin. When the classification was restricted to only the cells from each woman, a 100% correct identification of cell types was obtained, which supports the visual observation that there are cellular changes in the mammary epithelium correlated to the menstrual cycle. Since some proliferative changes may mimic atypia or malignancy, these findings suggest that it is advisable to perform needle aspirations of breast lesions during the preovulatory phase of the cycle.
在检查病变的细针穿刺物时，很明显排卵前的穿刺物与排卵后的不同。在黄体期吸出的细胞和碎片中观察到增殖活性。为了验证这一观察结果，通过计算机图像分析研究了8名育龄妇女在月经周期不同阶段获得的成对涂片。基于从数字化细胞图像中提取的核特征进行判别分析，根据涂片来源，84.87%的所有细胞被正确分类为排卵前或排卵后。当分类仅限于每个女性的细胞时，细胞类型的正确识别率达到100%，这支持了视觉观察结果，即乳腺上皮细胞存在与月经周期相关的变化。由于一些增殖性变化可能类似于异型性或恶性肿瘤，这些发现表明在月经周期的排卵前期对乳腺病变进行针吸是可取的。
