烯烃选择性和通用的钴催化氢氨甲基化反应制备胺类化合物
A Selective and General Cobalt-Catalyzed Hydroaminomethylation of Olefins to Amines.
作者信息
Yang Ji, Delolo Fábio G, Spannenberg Anke, Jackstell Ralf, Beller Matthias
机构信息
Leibniz-Institut für Katalyse e.V., Albert-Einstein-Straße 29a, 18059, Rostock, Germany.
Departamento de Química, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, 31270-901, Belo Horizonte, MG, Brazil.
出版信息
Angew Chem Int Ed Engl. 2022 Jan 10;61(2):e202112597. doi: 10.1002/anie.202112597. Epub 2021 Dec 2.
A new cobalt catalyst is presented for the domino hydroformylation-reductive amination reaction of olefins. The optimal Co-tert-BuPy-Xantphos catalyst shows good to excellent linear-to-branched (n/iso) regioselectivity for the reactions of aliphatic alkenes with aromatic amines under mild conditions. This system is far more selective than traditional cobalt(I) catalysts and even better than most known rhodium catalysts.
本文提出了一种用于烯烃多米诺氢甲酰化-还原胺化反应的新型钴催化剂。最佳的Co-tert-BuPy-Xantphos催化剂在温和条件下对脂肪族烯烃与芳香胺的反应表现出良好至优异的线性与支化（n/iso）区域选择性。该体系比传统的钴（I）催化剂选择性高得多，甚至优于大多数已知的铑催化剂。
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