The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, Cape Town, South Africa.
Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, USA.
AIDS Patient Care STDS. 2021 Nov;35(11):428-434. doi: 10.1089/apc.2021.0101.
Daily antiretroviral therapy (ART) suppresses viral replication, rendering HIV undetectable through viral load (VL) testing. People living with HIV (PLWH) who have an undetectable VL cannot transmit HIV to sexual partners or through giving birth, a message commonly referred to as U = U (undetectable equals untransmittable). To increase knowledge and understanding of U = U among men, who have poorer HIV testing and treatment outcomes than women, we engaged men from high HIV burden communities in Cape Town in two interactive human-centered design cocreation workshops to develop local U = U messaging for men. Two trained workshop facilitators, explained the U = U message to 39 adult men (in two separate workshops), and asked them how to effectively communicate U = U to other men in the local language (isiXhosa). Participant-designed messages sought to inform men about U = U to help assuage fears of testing HIV positive (by removing the stigma of living with HIV and being a vector of disease), and to explain that ART enables PLWH to live normal healthy lives, making HIV "untransmittable" to sex partners. Participants' messages emphasized that when virally suppressed, "" and "" Men cocreated simple local U = U messages to address fears of testing HIV positive and emphasizing ART's positive effects. Cocreated tailored messaging may reduce stigma associated with living with HIV and improve the uptake of HIV testing and treatment among South African men. This study was registered at clinicaltrials.gov under NCT04364165.
每日抗逆转录病毒疗法（ART）可抑制病毒复制，通过病毒载量（VL）检测使 HIV 无法检测到。HIV 感染者（PLWH）的 VL 无法检测到，就无法通过性接触或母婴传播将 HIV 传染给性伴侣或后代，这一信息通常被称为 U=U（无法检测到等于无法传播）。为了提高男性对 U=U 的认识和理解，因为与女性相比，男性的 HIV 检测和治疗结果更差，我们邀请开普敦高 HIV 负担社区的男性参加了两个互动的以人为中心的设计共创工作坊，为男性开发当地的 U=U 信息。两名经过培训的工作坊主持人向 39 名成年男性（在两个单独的工作坊中）解释了 U=U 信息，并询问他们如何用当地语言（isiXhosa）有效地向其他男性传达 U=U。参与者设计的信息旨在告知男性有关 U=U 的信息，以帮助减轻对 HIV 检测呈阳性的恐惧（通过消除与 HIV 共存和成为疾病传播媒介的耻辱感），并解释说 ART 使 PLWH 能够过上正常健康的生活，使 HIV“无法传播”给性伴侣。参与者的信息强调，当病毒受到抑制时，“”和“”。男性共同创作了简单的当地 U=U 信息，以解决对 HIV 检测呈阳性的恐惧，并强调 ART 的积极影响。共创的定制信息可能会减少与 HIV 共存相关的耻辱感，并提高南非男性接受 HIV 检测和治疗的意愿。这项研究在 clinicaltrials.gov 上注册，编号为 NCT04364165。
