甘草酸拮抗 HMGB1 可能对治疗 COVID-19 有成效。
HMGB1-antagonism exerted by glycyrrhizin could be fruitful against COVID-19.
机构信息
Consultant Allergist, Casa di Cura Villa Montallegro, Genoa, Italy.
International Federation ORL Societies (IFOS) Executive Board members Rome Italy.
出版信息
Acta Biomed. 2021 Oct 1;92(S6):e2021455. doi: 10.23750/abm.v92iS6.12111.
Abstract
The COVID-19 pandemic era is causing a relevant issue for the health. There is no specific drug able to antagonize the SARS-CoV-2 infection. As a consequence, there is growing interest about potential molecules able to contrast infection. In this regard, HMGB, an alarmin, may play a relevant role in pathogenic mechanisms induced by SARS-CoV-2. As HMGB1 is antagonized by glycyrrhizin, this substance could be potentially useful as ancillary treatment in COVID-19.
摘要
新冠疫情时期给健康带来了相关问题。目前尚无能够拮抗 SARS-CoV-2 感染的特效药物。因此，人们对可能具有抗感染作用的潜在分子产生了浓厚兴趣。在这方面，警报素高迁移率族蛋白 B1（HMGB1）可能在 SARS-CoV-2 诱导的发病机制中发挥重要作用。由于 HMGB1 可被甘草甜素拮抗，因此该物质可能对 COVID-19 的辅助治疗有用。
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