嗜酸细胞性慢性阻塞性肺疾病。
Eosinophilic Chronic Obstructive Pulmonary Disease.
机构信息
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center, 6201 Harry Hines Blvd, Dallas, TX, 75390-9223, USA.
出版信息
Lung. 2021 Dec;199(6):589-595. doi: 10.1007/s00408-021-00492-0. Epub 2021 Nov 5.
Abstract
Recent therapeutic advances in the management of asthma have underscored the importance of eosinophilia and the role of pro-eosinophilic mediators such as IL-5 in asthma. Given that a subset of patients with COPD may display peripheral eosinophilia similar to what is observed in asthma, a number of recent studies have implied that eosinophilic COPD is a distinct entity. This review will seek to contrast the mechanisms of eosinophilia in asthma and COPD, the implications of eosinophilia for disease outcome, and review current data regarding the utility of peripheral blood eosinophilia in the management of COPD patients.
摘要
最近在哮喘管理方面的治疗进展强调了嗜酸性粒细胞增多的重要性以及白细胞介素-5（IL-5）等促嗜酸性粒细胞介质在哮喘中的作用。鉴于一部分 COPD 患者可能表现出类似于哮喘中观察到的外周血嗜酸性粒细胞增多，最近的许多研究表明，嗜酸性粒细胞性 COPD 是一种独特的实体。这篇综述将试图对比哮喘和 COPD 中嗜酸性粒细胞增多的机制、嗜酸性粒细胞增多对疾病结局的影响，并回顾目前关于外周血嗜酸性粒细胞在 COPD 患者管理中的应用价值的数据。
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