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磁性-Fe₂O₃/Fe₃O₄ 异质结构纳米棒:制备及对 A549 细胞的细胞毒性。

Magnetic -Fe₂O₃/Fe₃O₄ Heterostructure Nanorods: Fabrication and Cytotoxicity to A549 Cells.

机构信息

School of Pharmacy, Jiangsu University, Zhenjiang 212013, P. R. China.

出版信息

J Nanosci Nanotechnol. 2021 Jun 1;21(6):3178-3182. doi: 10.1166/jnn.2021.19314.

DOI:10.1166/jnn.2021.19314
PMID:34739773
Abstract

The magnetic -Fe₂O₃/Fe₃O₄ heterostructure nanorods were fabricated by an alcohol-solution direct combustion method. The influence of the calcination temperature on the composition and properties of the nanorods was investigated. When the calcination temperature was not greater than 400 °C, the magnetic -Fe₂O₃/Fe₃O₄ heterostructure nanorods were obtained, and the saturation magnetization (Ms) of the magnetic -Fe₂O₃/Fe₃O₄ heterostructure nanorods decreased with the calcination temperature increasing from 250 °C to 400 °C; when the calcination temperature was equal or greater than 450 °C, -Fe2O3 nanorods were obtained. In addition, the effects of nanorods' concentration, nanorods' constituent, incubation time and magnetic field on A549 cytotoxicity were investigated. The cytotoxicity of the heterostructure nanorods appeared time-dependent and concentration-dependent, and the magnetic field could enhance the cytotoxicity of nanorods to A549.

摘要

通过醇溶液直接燃烧法制备了 Fe₂O₃/Fe₃O₄ 磁性异质结构纳米棒。研究了煅烧温度对纳米棒组成和性能的影响。当煅烧温度不高于 400°C 时,可以得到 Fe₂O₃/Fe₃O₄ 磁性异质结构纳米棒,并且随着煅烧温度从 250°C 升高到 400°C,磁性 Fe₂O₃/Fe₃O₄ 异质结构纳米棒的饱和磁化强度(Ms)降低;当煅烧温度等于或高于 450°C 时,则得到 Fe₂O₃ 纳米棒。此外,还研究了纳米棒浓度、纳米棒成分、孵育时间和磁场对 A549 细胞毒性的影响。异质结构纳米棒的细胞毒性呈现出时间依赖性和浓度依赖性,磁场可以增强纳米棒对 A549 的细胞毒性。

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