Department of Cardiology, HIA Sainte Anne Military Hospital, Toulon, France.
Department of Cardiology, HIA Laveran Military Hospital, Marseille, France.
Rev Med Interne. 2021 Nov;42(11):797-800. doi: 10.1016/j.revmed.2021.10.003. Epub 2021 Oct 19.
The etiology of myocarditis often remains undetermined. A large variety of infectious agents, systemic diseases, drugs, and toxins can cause the disease. We report the case of a 19-year-old man who developed myocarditis three days after Pfizer-BioNTech COVID-19 booster vaccination.
A 19-year-old man, presenting with troponin-positive acute chest pain, was referred to our department. He had received the Pfizer-BioNTech COVID-19 vaccine three days prior to his admission. The diagnosis of acute myocarditis was confirmed by cardiovascular magnetic resonance imaging. Patient hemodynamic status remained stable during hospitalization. The left ventricular ejection fraction was preserved during hospital stay and at one-month follow-up. We found no evidence for another infectious or autoimmune etiology.
Although imputability of the vaccine cannot be formally established on the basis of this case report, the findings raise the possibility of an association between mRNA COVID-19 vaccination and acute myocarditis.
心肌炎的病因往往不明确。多种感染因子、系统性疾病、药物和毒素均可导致该病。我们报告了 1 例 19 岁男性，在接受辉瑞-生物科技公司的 COVID-19 加强疫苗接种 3 天后发生心肌炎。
1 名 19 岁男性，因肌钙蛋白阳性的急性胸痛被转至我科。他在入院前 3 天接种了辉瑞-生物科技公司的 COVID-19 疫苗。心血管磁共振成像证实为急性心肌炎。患者在住院期间和 1 个月随访时血流动力学状态稳定。左心室射血分数在住院期间和 1 个月随访时保持正常。我们未发现其他感染或自身免疫病因的证据。
尽管不能根据该病例报告正式确定疫苗的可归因性，但这些发现提示 mRNA COVID-19 疫苗接种与急性心肌炎之间存在关联的可能性。
