Pulmonary and Critical Care Medicine, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, United States.
Division of Pediatric Infectious Disease, Department of Pediatrics, Oregon Health & Science University, Portland, OR. 97239, United States.
Vaccine. 2021 Dec 8;39(50):7295-7299. doi: 10.1016/j.vaccine.2021.10.044. Epub 2021 Nov 2.
Donor Unrestricted T Cells (DURTs) are characterized by their use of antigen presentation molecules that are often invariant. As these cells recognize diverse mycobacterial antigens, often found in BCG, these cells have the potential to either serve as targets for vaccination, or as a means to enable the induction of traditional T and B cell immunity. Here, we will review specific DURT family members, and their relationship to BCG.
供者非限制性 T 细胞（DURTs）的特征在于其使用的抗原呈递分子通常是不变的。由于这些细胞识别多种分枝杆菌抗原，这些抗原通常存在于卡介苗中，因此这些细胞有可能成为疫苗的靶标，或作为诱导传统 T 和 B 细胞免疫的手段。在这里，我们将回顾特定的 DURT 家族成员及其与卡介苗的关系。
