Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, 201203, China; Shanghai Engineering Research Center of ImmunoTherapeutics, And Key Laboratory of Smart Drug Delivery, School of Pharmacy, Fudan University, 201203, China.
Department of Rehabilitation, Huai'an Second People's Hospital, The Affiliated Hospital of Xuzhou Medical University, Huai'an, China.
Cancer Lett. 2022 Jan 28;525:84-96. doi: 10.1016/j.canlet.2021.10.034. Epub 2021 Nov 3.
Wnt/β-catenin signaling is a highly conserved pathway that regulates cell proliferation, differentiation, apoptosis, stem cell self-renewal, tissue homeostasis, and wound healing. Dysregulation of the Wnt pathway is intricately involved in almost all stages of tumorigenesis in various cancers. Through direct and/or indirect effects on effector T cells, T-regulatory cells, T-helper cells, dendritic cells, and other cytokine-expressing immune cells, abnormal activation of Wnt/β-catenin signaling benefits immune exclusion and hinders T-cell-mediated antitumor immune responses. Activation of Wnt signaling results in increased resistance to immunotherapies. In this review, we summarize the process by which Wnt signaling affects cancer and immune surveillance, and the potential for targeting the Wnt-signaling pathway via cancer immunotherapy.
Wnt/β-连环蛋白信号通路是一条高度保守的通路，调节细胞增殖、分化、凋亡、干细胞自我更新、组织平衡和伤口愈合。Wnt 通路的失调与各种癌症的肿瘤发生的几乎所有阶段都密切相关。通过直接和/或间接作用于效应 T 细胞、调节性 T 细胞、辅助性 T 细胞、树突状细胞和其他表达细胞因子的免疫细胞，Wnt/β-连环蛋白信号通路的异常激活有利于免疫排斥，并阻碍 T 细胞介导的抗肿瘤免疫反应。Wnt 信号的激活导致对免疫疗法的抵抗力增加。在这篇综述中，我们总结了 Wnt 信号影响癌症和免疫监视的过程，以及通过癌症免疫疗法靶向 Wnt 信号通路的潜力。
