Pamphilon D H, Creamer P, Keeling D H, Prentice A G
Eur J Haematol. 1987 Mar;38(3):279-83. doi: 10.1111/j.1600-0609.1987.tb01177.x.
A patient with polycythaemia vera developed typical myelofibrosis after 15 yr. After a further 8 months, during which time she was pancytopenic and transfusion-dependent, a slow spontaneous recovery in haemopoiesis occurred and the full blood count became normal. 6 months later pancytopenia recurred and soon afterwards the patient developed acute myeloblastic leukaemia from which she died. The evolution of bone marrow morphology and isotopic studies. Only 2 previous reports of this kind of transformation exist in the literature, although restoration of normal or polycythaemic haemopoiesis has been reported in 8 patients with myelofibrosis. It is likely that these transformations occur because of alterations in stem cell behaviour rather than as a result of therapy.
一名真性红细胞增多症患者在15年后发展为典型的骨髓纤维化。在接下来的8个月里，她全血细胞减少且依赖输血，之后造血功能缓慢自发恢复，全血细胞计数恢复正常。6个月后全血细胞减少再次出现，不久后患者发展为急性髓细胞白血病并死亡。骨髓形态学和同位素研究的演变。文献中仅存在2例此类转化的报道，尽管已有8例骨髓纤维化患者恢复正常或红细胞增多性造血的报道。这些转化可能是由于干细胞行为改变所致，而非治疗的结果。
