Weisenburger D D
Am J Clin Pathol. 1980 Jan;73(1):128-32. doi: 10.1093/ajcp/73.1.128.
The case of an 8-year-old girl in whom acute myelofibrosis developed is described. The patient was managed conservatively. A year later evolution to acute myeloblastic leukemia occurred, accompanied by myeloid and erythroid dyspoiesis and an elevated fetal hemoglobin level. A remarkable reversal of the marrow fibrosis occurred when the patient was treated with combination chemotherapy. Intensive chemotherapy combined with extensive transfusion support, and possibly bone marrow transplantation, may offer similar patients hope for a prolonged survival and possible cure. The nature of acute myelofibrosis and its differential diagnosis are discussed.
本文描述了一名8岁女童患急性骨髓纤维化的病例。该患者接受了保守治疗。一年后，病情进展为急性髓细胞白血病，伴有髓系和红系发育异常以及胎儿血红蛋白水平升高。当患者接受联合化疗时，骨髓纤维化出现了显著逆转。强化化疗联合广泛的输血支持，以及可能的骨髓移植，可能为类似患者带来延长生存期和可能治愈的希望。文中还讨论了急性骨髓纤维化的性质及其鉴别诊断。
