Hahlin M, Bokström H, Lindblom B
Fertil Steril. 1987 Jun;47(6):935-40.
An in vitro model for evaluation of pharmacologic treatment of ectopic pregnancy (EP) was designed. In cases of EP, specimens from the tubal wall, the tubal artery, and the corpus luteum capsule were used for contractility studies. In addition, tissue slices from the corpus luteum of EP were incubated for determination of progesterone production. In vitro administration of prostaglandin F2 alpha (PGF 2 alpha) induced a marked increase in activity of the tubal muscle and pronounced constriction of the tubal artery. PGF2 alpha also reduced the human chorionic gonadotropin-induced increase in progesterone production from the corpus luteum. PGE2 conversely, inhibited the tubal muscle activity and had a moderate constrictive effect on the tubal artery. Furthermore PGE2 increased the progesterone formation from the corpus luteum. In theory, the demonstrated in vitro effects indicate that as opposed to PGE2 compounds, PGF2 alpha compounds may be useful for pharmacologic treatment of EP.
设计了一种用于评估异位妊娠（EP）药物治疗的体外模型。对于EP病例，取自输卵管壁、输卵管动脉和黄体囊的标本用于收缩性研究。此外，对EP黄体的组织切片进行孵育以测定孕酮生成。体外给予前列腺素F2α（PGF 2α）可使输卵管肌肉活性显著增加，并使输卵管动脉明显收缩。PGF2α还可降低人绒毛膜促性腺激素诱导的黄体孕酮生成增加。相反，PGE2抑制输卵管肌肉活性，并对输卵管动脉有中度收缩作用。此外，PGE2可增加黄体的孕酮生成。理论上，所证明的体外效应表明，与PGE2化合物相反，PGF2α化合物可能对EP的药物治疗有用。
