Reynolds L P, Stigler J, Hoyer G L, Magness R R, Huie J M, Huecksteadt T P, Whysong G L, Behrman H R, Weems C W
Prostaglandins. 1981 Jun;21(6):957-72. doi: 10.1016/0090-6980(81)90164-7.
Fifty-six ewes were used to study the effects of PGE1 or PGE2 plus PGF2 alpha given into the perivascular space of the ovarian vascular pedicle on luteal function of nonbred ewes. All ewes receiving PGF2 alpha had reduced levels of plasma progesterone and unoccupied receptors for LH at 24 hr after treatment regardless even if they received PGE1 or PGE2 concomitantly. Levels of plasma progesterone in ewes receiving only PGF2 apha were reduced further at 48 hour. Plasma progesterone and unoccupied receptors for LH of ewes receiving PGE2 + PGF2 alpha were maintained at 48 hr at levels seen at 24 hr after treatment, while progesterone in ewes receiving PGE1 + PGF2 alpha at 48 hr returned to levels seen in controls at 48 hr and unoccupied receptors for LH were three fold greater than controls.
选用56只母羊来研究将前列腺素E1或前列腺素E2加前列腺素F2α注入卵巢血管蒂血管周围间隙对未孕母羊黄体功能的影响。所有接受前列腺素F2α的母羊，无论是否同时接受前列腺素E1或前列腺素E2，在治疗后24小时血浆孕酮水平和未被占据的促黄体生成素受体水平均降低。仅接受前列腺素F2α的母羊在48小时时血浆孕酮水平进一步降低。接受前列腺素E2 + 前列腺素F2α的母羊在48小时时血浆孕酮和未被占据的促黄体生成素受体维持在治疗后24小时时的水平，而接受前列腺素E1 + 前列腺素F2α的母羊在48小时时孕酮恢复到对照组48小时时的水平，且未被占据的促黄体生成素受体比对照组高三倍。
