Department of Nanotechnology, University of Kashmir, Hazratbal Campus, Srinagar JK-190006, India.
Department of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar JK-190011, India.
Int J Biol Macromol. 2021 Dec 15;193(Pt B):1151-1164. doi: 10.1016/j.ijbiomac.2021.10.133. Epub 2021 Nov 3.
Sine Oculis Homeobox 1 (SIX1) is a member of homeobox transcription factor family having pivotal roles in organismal development and differentiation. This protein functionally acts to regulate the expression of different proteins that are involved in organ development during embryogenesis and in disorders like cancer. Aberrant expression of this homeoprotein has therefore been reported in multiple pathological complexities like hearing impairment and renal anomalies during development and tumorigenesis in adult life. Most of the cellular effects mediated by it are mostly due to its role as a transcription factor. This review presents a concise narrative of its structure, interaction partners and cellular functions vis a vis its role in cancer. We thoroughly discuss the reported molecular mechanisms that govern its function in cellular milieu. Its post-translational regulation by phosphorylation and ubiquitination are also discussed with an emphasis on yet to be explored mechanistic insights regulating its molecular dynamics to fully comprehend its role in development and disease.
Sine Oculis Homeobox 1（SIX1）是同源盒转录因子家族的成员，在生物体的发育和分化中起着关键作用。该蛋白的功能是调节不同蛋白的表达，这些蛋白在胚胎发生过程中的器官发育以及癌症等疾病中发挥作用。因此，这种同源蛋白在家系蛋白的异常表达在听力障碍和肾脏畸形等多种病理复杂性中已有报道发育过程中和成年期的肿瘤发生。它介导的大多数细胞效应主要归因于其作为转录因子的作用。本综述简要叙述了其结构、相互作用伙伴和细胞功能及其在癌症中的作用。我们深入讨论了控制其在细胞环境中功能的报道分子机制。还讨论了其通过磷酸化和泛素化的翻译后调节，重点介绍了尚未探索的机制见解，以调节其分子动力学，从而充分理解其在发育和疾病中的作用。
