Wu Wangjun, Huang Ruihua, Wu Qinghua, Li Pinghua, Chen Jie, Li Bojiang, Liu Honglin
1. Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China; ; 2. Huaian Academy of Nanjing Agricultural University, Huaian, Jiangsu, 223001, China;
3. College of Life Science, Yangtze University, Jingzhou, Hubei, 434023, China. ; 4. Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kradec Kralove, Hradec Kralove, Czech Republic.
Int J Biol Sci. 2014 Sep 5;10(9):983-9. doi: 10.7150/ijbs.9442. eCollection 2014.
The sine oculis homeobox 1 (Six1) gene encodes an evolutionarily conserved transcription factor. In the past two decades, much research has indicated that Six1 is a powerful regulator participating in skeletal muscle development. In this review, we summarized the discovery and structural characteristics of Six1 gene, and discussed the functional roles and molecular mechanisms of Six1 in myogenesis and in the formation of skeletal muscle fibers. Finally, we proposed areas of future interest for understanding Six1 gene function.
眼无同源盒1（Six1）基因编码一种进化上保守的转录因子。在过去二十年中，大量研究表明Six1是参与骨骼肌发育的强大调节因子。在本综述中，我们总结了Six1基因的发现和结构特征，并讨论了Six1在肌发生和骨骼肌纤维形成中的功能作用及分子机制。最后，我们提出了未来理解Six1基因功能的研究方向。
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