个体的初级运动皮层β波段振荡经颅直流电刺激增强健康个体的皮质肌电相干性和皮质脊髓兴奋性。
Individualized beta-band oscillatory transcranial direct current stimulation over the primary motor cortex enhances corticomuscular coherence and corticospinal excitability in healthy individuals.
机构信息
Department of Physical Therapy, Yamagata Prefectural University of Health Sciences, 260 Kamiyanagi, Yamagata-shi, Yamagata, 990-2212, Japan; Department of Physical Therapy, Graduate School of Health Sciences, Yamagata Prefectural University of Health Sciences, 260 Kamiyanagi, Yamagata-shi, Yamagata, 990-2212, Japan.
Department of Physical Therapy, Graduate School of Health Sciences, Yamagata Prefectural University of Health Sciences, 260 Kamiyanagi, Yamagata-shi, Yamagata, 990-2212, Japan.
出版信息
Brain Stimul. 2022 Jan-Feb;15(1):46-52. doi: 10.1016/j.brs.2021.11.004. Epub 2021 Nov 3.
BACKGROUND
Simultaneously modulating individual neural oscillation and cortical excitability may be important for enhancing communication between the primary motor cortex and spinal motor neurons, which plays a key role in motor control. However, it is unknown whether individualized beta-band oscillatory transcranial direct current stimulation (otDCS) enhances corticospinal oscillation and excitability.
OBJECTIVE
This study investigated the effects of individualized beta-band otDCS on corticomuscular coherence (CMC) and corticospinal excitability in healthy individuals.
METHODS
In total, 29 healthy volunteers participated in separate experiments. They received the following stimuli for 10 min on different days: 1) 2-mA otDCS with individualized beta-band frequencies, 2) 2-mA transcranial alternating current stimulation (tACS) with individualized beta-band frequencies, and 3) 2-mA transcranial direct current stimulation (tDCS). The changes in CMC between the vertex and tibialis anterior (TA) muscle and TA muscle motor-evoked potentials (MEPs) were assessed before and after (immediately, 10 min, and 20 min after) stimulation on different days. Additionally, 20-Hz otDCS for 10 min was applied to investigate the effects of a fixed beta-band frequency on CMC.
RESULTS
otDCS significantly increased CMC and MEPs immediately after stimulation, whereas tACS and tDCS had no effects. There was a significant negative correlation between normalized CMC changes in response to 20-Hz otDCS and the numerical difference between the 20-Hz and individualized CMC peak frequency before the stimulation.
CONCLUSIONS
These findings suggest that simultaneous modulation of neural oscillation and cortical excitability is critical for enhancing corticospinal communication. Individualized otDCS holds potential as a useful method in the field of neurorehabilitation.
背景
同时调节个体神经振荡和皮质兴奋性对于增强初级运动皮层和脊髓运动神经元之间的通信可能很重要，这在运动控制中起着关键作用。然而，目前尚不清楚个体化β波段振荡经颅直流电刺激（otDCS）是否增强皮质脊髓振荡和兴奋性。
目的
本研究旨在探讨个体化β波段 otDCS 对健康个体皮质肌电相干性（CMC）和皮质脊髓兴奋性的影响。
方法
共有 29 名健康志愿者参加了不同的实验。他们在不同的日子接受了以下刺激 10 分钟：1）个体化β波段频率的 2 mA otDCS；2）个体化β波段频率的 2 mA 经颅交流电刺激（tACS）；3）2 mA 经颅直流电刺激（tDCS）。在不同的日子，在刺激前后（立即、刺激后 10 分钟和 20 分钟）评估顶点和胫骨前肌（TA）之间的 CMC 变化以及 TA 肌肉运动诱发电位（MEP）。此外，施加了 10 分钟的 20-Hz otDCS，以研究固定β波段频率对 CMC 的影响。
结果
otDCS 可显著增加刺激后的 CMC 和 MEP，而 tACS 和 tDCS 则没有效果。在刺激前，归一化 CMC 变化对 20-Hz otDCS 的响应与 20-Hz 和个体化 CMC 峰值频率之间的数值差异之间存在显著的负相关。
结论
这些发现表明，神经振荡和皮质兴奋性的同步调节对于增强皮质脊髓通信至关重要。个体化 otDCS 可能成为神经康复领域的一种有用方法。
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