P.G. Department of Zoology, Magadh University, Bodh Gaya, Bihar 824234, India.
Department of Zoology, University of Delhi, Delhi 110007, India.
Exp Biol Med (Maywood). 2022 Jan;247(2):152-164. doi: 10.1177/15353702211046927. Epub 2021 Nov 7.
Huntington's disease (HD) is a devastating polyglutamine disorder characterized by extensive neurodegeneration and metabolic abnormalities at systemic, cellular and intracellular levels. Metabolic alterations in HD manifest as abnormal body weight, dysregulated biomolecule levels, impaired adipocyte functions, and defective energy state which exacerbate disease progression and pose acute threat to the health of challenged individuals in form of insulin resistance, cardiovascular disease, and energy crisis. To colossally mitigate disease symptoms, we tested the efficacy of curcumin in model of HD. Curcumin is the bioactive component of turmeric ( Linn), well-known for its ability to modulate metabolic activities. We found that curcumin effectively managed abnormal body weight, dysregulated lipid content, and carbohydrate level in HD flies. In addition, curcumin administration lowered elevated reactive-oxygen-species levels in adult adipose tissue of diseased flies, and improved survival and locomotor function in HD flies at advanced disease stage. Altogether, these findings clearly suggest that curcumin efficiently attenuates metabolic derangements in HD flies and can prove beneficial in alleviating the complexities associated with HD.
亨廷顿病（HD）是一种破坏性的多聚谷氨酰胺疾病，其特征是在全身、细胞和细胞内水平上广泛的神经退行性变和代谢异常。HD 中的代谢改变表现为异常体重、生物分子水平失调、脂肪细胞功能受损以及能量状态缺陷，这些都会加剧疾病的进展，并以胰岛素抵抗、心血管疾病和能量危机的形式对受挑战个体的健康构成急性威胁。为了极大地减轻疾病症状，我们在 HD 模型中测试了姜黄素的功效。姜黄素是姜黄（ Linn）的生物活性成分，以其调节代谢活动的能力而闻名。我们发现姜黄素可有效控制 HD 果蝇的异常体重、脂质含量和碳水化合物水平。此外，姜黄素给药可降低患病果蝇成年脂肪组织中升高的活性氧水平，并可提高 HD 果蝇在疾病晚期的存活率和运动功能。总之，这些发现清楚地表明，姜黄素可有效减轻 HD 果蝇的代谢紊乱，并可有助于缓解与 HD 相关的复杂性。
