Department of Radiology, Key Laboratory of Intelligent Computing in Medical Image, Ministry of Education, Shengjing Hospital of China Medical University, No.36, Sanhao Street, Heping District, Shenyang, 110004, Liaoning, People's Republic of China.
Department of Medical Imaging, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, People's Republic of China.
J Cardiothorac Surg. 2021 Nov 7;16(1):325. doi: 10.1186/s13019-021-01709-2.
To investigate the relationship of pericoronary adipose tissue (PCAT) with coronary artery stenosis using dual-layer spectral detector CT (SDCT).
99 patients were retrospectively divided into normal group, non-significant stenosis group and significant stenosis group (n = 33 in each group). Fat attenuation index (FAI) 40kev, spectral curve slope (λHU), effective atomic number (Eff-Z) and epicardial fat volume (EFV) were quantitatively evaluated of the narrowest part of the lesion tissue by SDCT.
There were significant differences in PCAT parameters on SDCT (FAI40keV, λHU, Eff-Z and EFV) among the three groups (P < 0.05). FAI40keV, λHU, and Eff-Z in significant stenosis group were statistically different from those in normal group and non-significant stenosis group (P < 0.05). FAI40keV, λHU, and Eff-Z in non-significant stenosis group were statistically different from significant stenosis group (P < 0.05). EFV in normal group were significantly lower in non-significant stenosis group and significant stenosis group (P < 0.001). Univariate and multivariate logistic regression analyses identified FAI40keV (OR = 1.50, 95%CI 1.01 to 1.09) and λHU (OR = 6.81, 95%CI 1.87 to 24.86) as independent predictors of significant stenosis. FAI40keV and λHU had quite good discrimination, with an AUC of 0.84 and 0.80 respectively.
FAI40keV, λHU, and Eff-Z on SDCT in significant stenosis group were significantly different from normal and non-significant stenosis group while EFV in normal group were significantly different from non-significant stenosis group and significant stenosis group. FAI40kev and λHU were risk factors for significant stenosis.
利用双层光谱探测器 CT（SDCT）研究冠状动脉狭窄与心外膜脂肪组织（PCAT）的关系。
回顾性分析 99 例患者，根据冠状动脉狭窄程度分为正常组、非狭窄组和狭窄组（每组 33 例）。采用 SDCT 定量分析病变组织最狭窄处的脂肪衰减指数（FAI40keV）、光谱曲线斜率（λHU）、有效原子序数（Eff-Z）和心外膜脂肪体积（EFV）。
三组患者 PCAT 参数（SDCT 的 FAI40keV、λHU、Eff-Z 和 EFV）差异有统计学意义（P<0.05）。狭窄组 FAI40keV、λHU 和 Eff-Z 与正常组和非狭窄组比较，差异有统计学意义（P<0.05）。非狭窄组 FAI40keV、λHU 和 Eff-Z 与狭窄组比较，差异有统计学意义（P<0.05）。正常组 EFV 明显低于非狭窄组和狭窄组（P<0.001）。单因素和多因素 logistic 回归分析表明 FAI40keV（OR=1.50，95%CI 1.011.09）和 λHU（OR=6.81，95%CI 1.8724.86）是狭窄的独立预测因子。FAI40keV 和 λHU 具有较好的鉴别能力，AUC 分别为 0.84 和 0.80。
SDCT 中狭窄组的 FAI40keV、λHU 和 Eff-Z 与正常组和非狭窄组差异有统计学意义，而正常组的 EFV 与非狭窄组和狭窄组差异有统计学意义。FAI40keV 和 λHU 是狭窄的危险因素。
