冠状动脉周围脂肪组织与冠状动脉疾病和左心室功能的相关性。
The correlation of pericoronary adipose tissue with coronary artery disease and left ventricular function.
机构信息
Department of Radiology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, 213003, Jiangsu, China.
Department of Interventional and Vascular Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, 213003, China.
出版信息
BMC Cardiovasc Disord. 2022 Sep 6;22(1):398. doi: 10.1186/s12872-022-02843-y.
OBJECTIVE
We sought to investigate the correlation of pericoronary adipose tissue with coronary artery disease and left ventricular (LV) function.
METHODS
Participants with clinically suspected coronary artery disease were enrolled. All participants underwent coronary computed tomography angiography (CCTA) and echocardiography followed by invasive coronary angiography (ICA) within 6 months. Pericoronary adipose tissue (PCAT) was extracted to analyze the correlation with the Gensini score and LV function parameters, including IVS, LVPW, LVEDD, LVESD, LVEDV, LVESV, FS, LVEF, LVM, and LVMI. The correlation between PCAT and the Gensini score was assessed using Spearman's correlation analysis, and that between the PCAT volume or FAI and LV function parameters was determined using partial correlation analysis.
RESULTS
One hundred and fifty-nine participants (mean age, 64.55 ± 10.64 years; men, 65.4% [104/159]) were included in the final analysis. Risk factors for coronary artery disease, such as hypertension, diabetes, dyslipidemia, and a history of smoking or drinking, had no significant association with PCAT (P > 0.05), and there was also no correlation between PCAT and the Gensini score. However, the LAD-FAI was positively correlated with the IVS (r = 0.203, P = 0.013), LVPW (r = 0.218, P = 0.008), LVEDD (r = 0.317, P < 0.001), LVESD (r = 0.298, P < 0.001), LVEDV (r = 0.317, P < 0.001), LVESV (r = 0.301, P < 0.001), LVM (r = 0.371, P < 0.001), and LVMI (r = 0.304, P < 0.001). Also, the LCX-FAI was positively correlated with the LVEDD (r = 0.199, P = 0.015), LVESD (r = 0.190, P = 0.021), LVEDV (r = 0.203, P = 0.013), LVESV (r = 0.197, P = 0.016), LVM (r = 0.220, P = 0.007), and LVMI (r = 0.172, P = 0.036), and the RCA-FAI was positively correlated with the LVEDD (r = 0.258, P = 0.002), LVESD (r = 0.238, P = 0.004), LVEDV (r = 0.266, P = 0.001), LVESV (r = 0.249, P = 0.002), LVM (r = 0.237, P = 0.004), and LVMI (r = 0.218, P = 0.008), respectively. Finally, the total volume was positively correlated with FS (r = 0.167, P = 0.042).
CONCLUSION
The FAI was positively correlated with the LV function but was not associated with the severity of coronary artery disease.
目的
我们旨在探讨冠状动脉疾病与左心室（LV）功能与冠状周脂肪组织（PCAT）之间的相关性。
方法
入选有临床疑似冠状动脉疾病的患者。所有患者在 6 个月内行冠状动脉计算机断层扫描血管造影（CCTA）和超声心动图检查，随后行有创性冠状动脉造影（ICA）。提取冠状周脂肪组织（PCAT），分析其与 Gensini 评分和 LV 功能参数的相关性，包括室间隔（IVS）、左心室后壁（LVPW）、左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）、左心室舒张末期容积（LVEDV）、左心室收缩末期容积（LVESV）、射血分数（FS）、左心室射血分数（LVEF）、左心室质量（LVM）和左心室质量指数（LVMI）的相关性。采用 Spearman 相关分析评估 PCAT 与 Gensini 评分之间的相关性，采用偏相关分析评估 PCAT 体积或 FAI 与 LV 功能参数之间的相关性。
结果
最终有 159 名患者（平均年龄 64.55±10.64 岁，男性 65.4%[104/159]）纳入最终分析。冠状动脉疾病的危险因素，如高血压、糖尿病、血脂异常以及吸烟或饮酒史，与 PCAT 无显著相关性（P＞0.05），且 PCAT 与 Gensini 评分之间也无相关性。然而，LAD-FAI 与 IVS（r=0.203，P=0.013）、LVPW（r=0.218，P=0.008）、LVEDD（r=0.317，P＜0.001）、LVESD（r=0.298，P＜0.001）、LVEDV（r=0.317，P＜0.001）、LVESV（r=0.301，P＜0.001）、LVM（r=0.371，P＜0.001）和 LVMI（r=0.304，P＜0.001）呈正相关。同样，LCX-FAI 与 LVEDD（r=0.199，P=0.015）、LVESD（r=0.190，P=0.021）、LVEDV（r=0.203，P=0.013）、LVESV（r=0.197，P=0.016）、LVM（r=0.220，P=0.007）和 LVMI（r=0.172，P=0.036）呈正相关，RCA-FAI 与 LVEDD（r=0.258，P=0.002）、LVESD（r=0.238，P=0.004）、LVEDV（r=0.266，P=0.001）、LVESV（r=0.249，P=0.002）、LVM（r=0.237，P=0.004）和 LVMI（r=0.218，P=0.008）呈正相关。最后，总体积与 FS（r=0.167，P=0.042）呈正相关。
结论
FAI 与 LV 功能呈正相关，但与冠状动脉疾病的严重程度无关。
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