Taoka H, Ando Y, Kurumiya T, Ohta M, Sanda T, Shimizu T, Okabayashi Y
Nihon Geka Gakkai Zasshi. 1987 May;88(5):543-50.
We measured CA19-9 value in feces of 119 cases with malignant disease, 78 cases with benign diseases and 36 healthy volunteers, and studied its usefulness for the diagnosis of digestive tract cancer. Mean value of CA19-9 in feces of healthy volunteer was 276.4 +/- 643.3 U/ml (mean +/- 2S.D.) and cut off value was defined as 1000 U/ml. The positive ratio of CA19-9 in feces of patients with malignant diseases as 44.5%. On the other hand, the mean of the false positive ratio was only 1.4% in benign diseases. Regarding to its breakdown, CA19-9 in feces revealed the highest positive ratio as 68% in colonic cancer. In colonic cancer, CA19-9 in feces showed a high positive ratio of 83% at advanced stage. Histologically, the positive ratios of CA19-9 in feces were higher, such as in more than 80% of the reaching degree of depth ss, a1, more than 82% of the disease due to higher parasites of lymph vessel ly1 and more than 95% of the metastasis of lymph node n1. Moreover, all CA19-9 in feces were positive in positive cases of CEA in serum.
我们检测了119例恶性疾病患者、78例良性疾病患者及36名健康志愿者粪便中的CA19-9值，并研究其对消化道癌症诊断的效用。健康志愿者粪便中CA19-9的平均值为276.4±643.3 U/ml（平均值±2标准差），临界值定义为1000 U/ml。恶性疾病患者粪便中CA19-9的阳性率为44.5%。另一方面，良性疾病中的假阳性率平均值仅为1.4%。就其分类而言，粪便中的CA19-9在结肠癌中的阳性率最高，为68%。在结肠癌中，粪便中的CA19-9在晚期的阳性率高达83%。组织学上，粪便中CA19-9的阳性率较高，如在深度ss、a1达到程度超过80%时，淋巴管ly1高度寄生导致的疾病超过82%时，以及淋巴结n1转移超过95%时。此外，血清CEA阳性病例中粪便中的所有CA19-9均为阳性。
