马来酸桂哌齐特对重症脑出血术后ICU患者血清炎症因子的影响
Effect of Cinepazide Maleate on Serum Inflammatory Factors of ICU Patients with Severe Cerebral Hemorrhage after Surgery.
作者信息
Zhang Jing, Zhang Xia, Shang Yun, Zhang Li
机构信息
Department of Internal Medicine-Neurology, Linyi Central Hospital, Linyi 276400, Shandong Province, China.
Endoscopy Room, The Fourth People's Hospital of Jinan, Jinan 250031, Shandong Province, China.
出版信息
Evid Based Complement Alternat Med. 2021 Oct 28;2021:6562140. doi: 10.1155/2021/6562140. eCollection 2021.
OBJECTIVE
To explore the effect of cinepazide maleate on serum inflammatory factors of intensive care unit (ICU) patients with severe cerebral hemorrhage after surgery.
METHODS
116 ICU patients with severe cerebral hemorrhage treated in Taian Maternal and Child Health Hospital from June 2018 to June 2020 were selected as the research objects and randomly divided into the control group and experimental group, with 58 patients in each group. The control group was given routine treatment, while the experimental group was additionally given an intravenous drip of cinepazide maleate to compare the clinical efficacy and serum inflammatory factors between the two groups.
RESULTS
The total effective rate in the experimental group was higher than that in the control group ( < 0.05). After treatment, the Glasgow Coma Scale (GCS), National Institutes of Health Stroke Scale (NIHSS), and Fugl-Meyer scores in both groups were better than those before treatment, and the scores in the experimental group were better than those in the control group ( < 0.05). The oxidative stress indexes such as total antioxidant capacity (T-Aoc), superoxide dismutase (SOD), and glutathione peroxidase (GSH-PX) in the experimental group were higher than those in the control group, while malondialdehyde (MDA) in the experimental group was lower than that in the control group ( < 0.05). The high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor- (TNF-) levels in the experimental group were lower than those in the control group ( < 0.05). Compared with the control group, the cerebrovascular function in the experimental group was significantly improved ( < 0.05), with statistically significant differences.
CONCLUSION
Cinepazide maleate can effectively reduce the serum inflammatory factor levels of ICU patients with severe cerebral hemorrhage after surgery, alleviate the oxidative stress response in the body, and improve the cerebrovascular function and cerebral nerve function, which is worthy of clinical promotion.
目的
探讨马来酸桂哌齐特对重症监护病房（ICU）重症脑出血术后患者血清炎症因子的影响。
方法
选取2018年6月至2020年6月在泰安市妇幼保健院治疗的116例ICU重症脑出血患者作为研究对象，随机分为对照组和实验组，每组58例。对照组给予常规治疗，实验组额外静脉滴注马来酸桂哌齐特，比较两组的临床疗效和血清炎症因子。
结果
实验组总有效率高于对照组（<0.05）。治疗后，两组的格拉斯哥昏迷量表（GCS）、美国国立卫生研究院卒中量表（NIHSS）和Fugl-Meyer评分均优于治疗前，且实验组评分优于对照组（<0.05）。实验组的总抗氧化能力（T-Aoc）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-PX）等氧化应激指标高于对照组，而实验组的丙二醛（MDA）低于对照组（<0.05）。实验组的高敏C反应蛋白（hsCRP）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）和肿瘤坏死因子-（TNF-）水平低于对照组（<0.05）。与对照组相比，实验组脑血管功能明显改善（<0.05），差异有统计学意义。
结论
马来酸桂哌齐特可有效降低ICU重症脑出血术后患者血清炎症因子水平，减轻机体氧化应激反应，改善脑血管功能和脑神经功能，值得临床推广。
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